Ingestible medical delivery devices
Exemplary embodiments of the disclosure may be drawn to ingestible delivery devices. An ingestible delivery device may include a first compartment and a second compartment. A lipase may be contained within the first compartment, and a fat may be contained within the second compartment. The first compartment may be sealed from the second compartment prior to exposure to a trigger, preventing the lipase and the fat from contacting each other, and at least one of the first compartment or the second compartment may at least partially rupture upon exposure to the trigger, allowing the lipase and the fat to contact each other.
1. A method comprising:
administering an ingestible delivery device to a subject suspected of traumatic brain injury, wherein the ingestible delivery device comprises:
a first compartment;
a second compartment;
a lipase contained within the first compartment; and
a fat contained within the second compartment;
wherein the first compartment is sealed from the second compartment prior to exposure to a trigger, preventing the lipase and the fat from intermixing, and wherein at least one of the first compartment or the second compartment at least partially ruptures upon exposure to the trigger, allowing the lipase and the fat to intermix with each other so that the lipase hydrolyzes the fat, forming free fatty acids and monoglycerides;
wherein the trigger causes the ingestible delivery device to rupture in a small intestine of the subject, delivering free fatty acids and monoglycerides to the small intestine of the subject.
2. The method of claim 1 , wherein the fat is an omega-3 fatty acid, and wherein the device further comprises at least one of resveratrol, curcumin, magnesium, co-enzyme Q10, turmeric, or creatine.
3. The method of claim 1 , wherein the ingestible delivery device is administered to the subject at least 4 hours after the subject last ate food and/or without food.
4. The method of claim 1 , wherein the ingestible delivery device is administered to the subject with water.
5. The method of claim 1 , wherein the ingestible delivery device is administered to the subject within 1 hour of an event that caused the suspected traumatic brain injury.
6. A method comprising:
administering an ingestible delivery device to a subject who has not eaten food for at least 4 hours, wherein the ingestible delivery device comprises:
a first compartment;
a second compartment;
a lipase contained within the first compartment; and
a fat contained within the second compartment;
wherein the first compartment is sealed from the second compartment prior to exposure to a trigger, preventing the lipase and the fat from intermixing, and wherein at least one of the first compartment or the second compartment at least partially ruptures upon exposure to the trigger, allowing the lipase and the fat to intermix with each other so that the lipase hydrolyzes the fat, forming free fatty acids and monoglycerides;
wherein the trigger causes the ingestible delivery device to rupture in a small intestine of the subject, delivering free fatty acids and monoglycerides to the small intestine of the subject.
7. The method of claim 6 , wherein the ingestible delivery device is administered to the subject with water and/or without food.
8. The method of claim 6 , wherein the ingestible delivery device is administered to the subject within 1 hour of an event that caused suspected traumatic brain injury.
9. The method of claim 6 , wherein the fat is an omega-3 fatty acid, and wherein the device further comprises at least one of resveratrol, curcumin, magnesium, co-enzyme Q10, turmeric, or creatine.
10. The method of claim 1 , wherein the trigger is at least one of (i) a compressive pressure applied to the device, (ii) a neutral pH, or (iii) an alkaline pH.
11. The method of claim 1 , wherein the first compartment is sealed from the second compartment by a barrier wall.
12. The method of claim 11 , wherein the barrier wall partitions the ingestible delivery device into the first compartment and the second compartment.
13. The method of claim 6 , wherein the trigger is at least one of (i) a compressive pressure applied to the device, (ii) a neutral pH, or (iii) an alkaline pH.
14. The method of claim 6 , wherein the first compartment is sealed from the second compartment by a barrier wall.
15. The method of claim 14 , wherein the barrier wall partitions the ingestible delivery device into the first compartment and the second compartment.
16. The method of claim 1 , wherein the ingestible delivery device is administered to the subject within one minute of an event that caused the suspected traumatic brain injury.
17. The method of claim 1 , wherein the ingestible delivery device is administered to the subject within 20 minutes of an event that caused the suspected traumatic brain injury.
18. The method of claim 6 , wherein the ingestible delivery device is administered to the subject within one minute of an event that caused suspected traumatic brain injury.
19. The method of claim 6 , wherein the ingestible delivery device is administered to the subject daily.
20. The method of claim 6 , wherein the ingestible delivery device is administered to the subject prior to an activity where the subject is at risk for a traumatic brain injury.