IP Library › Patent Application 16921422
Patent Application
App. No. 16/921,422

PHARMACEUTICAL COMPOSITION COMPRISING A GLP-1-AGONIST AND METHIONINE

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Quick Facts
Patent No.
US None
App. No.
16/921,422
Abstract

A liquid composition comprising a GLP-1 agonist or/and a pharmacologically tolerable salt thereof and, optionally, at least one pharmaceutically acceptable excipient, wherein the composition comprises methionine, as add-on therapy with metformin and/or with long-acting insulin/insulin derivates where appropriate.

Claims (14)

1 . An aqueous liquid composition consisting essentially of:

(a) desPro 36 exendin-4(1-39)-Lys 6 -NH2 (“AVE0010”) or a pharmacologically tolerable salt thereof at a concentration of about 0.025 mg/mL to about 0.1 mg/mL;

(b) insulin glargine or a pharmacologically tolerable salt thereof at a concentration of about 3.64 mg/mL;

(c) L-methionine;

(d) m-cresol;

(e) 85% glycerol;

(f) zinc chloride, and

(g) water in a quantity sufficient for the volume of the composition to total about 1 mL.

2 . The aqueous liquid composition of claim 1 , wherein the composition consists essentially of:

(c) about 3 mg L-methionine;

(d) about 2.7 mg m-cresol;

(e) about 20 mg 85% glycerol; and

(f) about 0.06 mg zinc chloride.

3 . The aqueous liquid composition of claim 1 , wherein the composition further consists essentially of hydrochloric acid and sodium hydroxide such that the composition has a pH in the range of 3.5 to 4.5.