1,2,4-oxadiazole and thiadiazole compounds as immunomodulators
The present invention relates to 1,2,4-oxadiazole and thiadiazole compounds of formula (I) and their use to inhibit the programmed cell death 1 (PD1) signaling pathway and/or for treatment of disorders by inhibiting an immunosuppressive signal induced by PD-1, PD-L1 or PD-L2.
1. A method of treating cancer in a subject in need thereof, comprising administering to the subject a compound selected from:
or a pharmaceutically acceptable salt thereof.
2. The method of claim 1 , wherein the compound is
or a pharmaceutically acceptable salt thereof.
3. The method of claim 1 , wherein the compound is
or a pharmaceutically acceptable salt thereof.
4. The method of claim 1 , wherein the compound is
or a pharmaceutically acceptable salt thereof.
5. The method of claim 1 , wherein the compound is
or a pharmaceutically acceptable salt thereof.
6. The method of claim 1 , wherein the compound is
or a pharmaceutically acceptable salt thereof.
7. The method of claim 1 , wherein the compound is
or a pharmaceutically acceptable salt thereof.
8. The method of claim 1 , wherein the compound is
or a pharmaceutically acceptable salt thereof.
9. The method of claim 1 , wherein the compound is
or a pharmaceutically acceptable salt thereof.
10. The method of claim 1 , wherein the compound is
or a pharmaceutically acceptable salt thereof.
11. The method of claim 1 , wherein the compound is
or a pharmaceutically acceptable salt thereof.
12. The method of claim 1 , wherein the compound is
or a pharmaceutically acceptable salt thereof.
13. The method of claim 1 , wherein the compound is
or a pharmaceutically acceptable salt thereof.
14. The method of claim 1 , wherein the compound is
or a pharmaceutically acceptable salt thereof.
15. The method of claim 1 , wherein the compound is
or a pharmaceutically acceptable salt thereof.
16. The method of claim 1 , wherein the compound is
17. The method of claim 1 , wherein the compound is
18. The method of claim 1 , wherein the compound is
19. The method of claim 1 , wherein the compound is
20. The method of claim 1 , wherein the compound is
21. The method of claim 1 , wherein the compound is
22. The method of claim 1 , wherein the compound is
23. The method of claim 1 , wherein the compound is
24. The method of claim 1 , wherein the compound is
25. The method of claim 1 , wherein the compound is
26. The method of claim 1 , wherein the compound is
27. The method of claim 1 , wherein the compound is
28. The method of claim 1 , wherein the compound is
29. The method of claim 1 , wherein the compound is
30. The method of claim 1 , wherein the cancer is selected from lung cancer, breast cancer, colon cancer, renal cancer, bladder cancer, thyroid cancer, prostate cancer, osteosarcoma, or Hodgkin's lymphoma.