Compositions and methods for treating allergic inflammatory conditions
The invention provides methods of treating an allergic inflammatory condition characterized by inflammation of the squamous epithelium of a target tissue by administering to the subject a pharmaceutical composition comprising a kallikrein 5 (KLK5) inhibitor, and a pharmaceutically acceptable carrier.
1. A method of treating an allergic inflammatory condition in a subject in need thereof, the allergic inflammatory condition characterized by inflammation of a squamous epithelium in a target tissue of the subject, the method comprising administering to the subject a pharmaceutical composition comprising a kallikrein 5 (KLK5) inhibitor, and a pharmaceutically acceptable carrier, wherein the target tissue is esophageal tissue and the allergic inflammatory condition is eosinophilic esophagitis (EoE).
2. The method of claim 1 , wherein the method comprises administering an amount of the KLK5 inhibitor effective to suppress KLK5 proteinase activity in the target tissue.
3. The method of claim 1 , wherein the subject is human.