Smart healthcare system
A system is provided for advanced health monitoring and diagnosis based on wearable nano-biosensing networks. Nanophotonic and wireless communication technologies are synergistically leveraged to bridge the gap between nano-biosensing technologies and commercial wearable devices. Embodiments of the presently-disclosed system may include: (1) a nanoplasmonic biochip, implanted subcutaneously and built on a flexible substrate; (2) a nanophotonic smart band or wearable device that is able to collect in-vivo signals on-demand and relay them wirelessly to the user's smartphone by means of a secure data transfer; and (3) advanced signal processing techniques implemented on a remote processor to extract relevant data from the received signals and provide a diagnosis in real-time.
1. A system for detecting and measuring biomarkers, comprising:
an implantable sensor configured to be implanted in an individual, comprising:
an array of Surface Plasmon Resonance (SPR) biosensors; and
a plurality of optical couplers located at a top surface of the implantable sensor, each optical coupler operatively configured such that light received at the optical coupler is focused to a corresponding biosensor of the array of SPR biosensors;
an interface device configured to be worn by the individual proximate to the implantable sensor, comprising:
a plurality of emitters, each emitter configured to emit light to a corresponding optical coupler of the implantable sensor; and
a plurality of detectors, each detector configured to receive light reflected by a corresponding biosensor of the implantable sensor.
2. The system of claim 1 , wherein the array of SPR biosensors comprises:
a substrate with a top surface and a bottom surface, wherein the top surface is configured to be positioned toward the exterior of the user's body when implanted;
a plurality of gratings arranged on the bottom surface of the substrate; and
an SPR film on the plurality of gratings.
3. The system of claim 1 , wherein the SPR film is a metallic film.
4. The system of claim 1 , further comprising a biocompatible gel between the substrate and the plurality of gratings.
5. The system of claim 1 , wherein each emitter in the plurality of emitters is a laser.
6. The system of claim 5 , wherein each laser in the plurality of emitters is an orbital angular momentum microlaser.
7. The system of claim 5 , wherein each laser in the plurality of emitters is a single-mode microring laser.
8. The system of claim 5 , wherein each laser in the plurality of emitters is a three-dimensional subwavelength metallo-dielectric semiconductor laser.
9. The system of claim 8 , wherein each three-dimensional subwavelength metallo-dielectric semiconductor laser incorporates a dielectric shield layer.
10. The system of claim 1 , wherein the interface device further comprises an interface processor, wherein the interface processor post-equalizes a measured signal, filters stochastic and ambient background noise from the measured signal, and combines the measured signal at each nano-photonic detector.
11. The system of claim 1 , wherein the interface device further comprises a transceiver.
12. The system of claim 11 , wherein the transceiver is a Bluetooth transceiver.
13. The system of claim 1 , further comprising a remote processor in wireless communication with the interface device.
14. The system of claim 13 , wherein the remote processor is a smartphone.
15. The system of claim 13 , wherein the remote processor is configured to transmit the data to a practitioner for analysis.
16. The system of claim 13 , wherein the remote processor is configured to process the data into an anonymous data set and store the anonymous data set on a data server.