Benzamide compounds

1. A compound of Formula (I), or a pharmaceutically acceptable salt thereof, having the structure:

wherein:

R 1 is selected from the group consisting of hydrogen, halogen, a substituted or unsubstituted C 1 -C 6 alkyl, a substituted or unsubstituted C 1 -C 6 haloalkyl, a substituted or unsubstituted C 3 -C 6 cycloalkyl, a substituted or unsubstituted C 1 -C 6 alkoxy, an unsubstituted mono-C 1 -C 6 alkylamine and an unsubstituted di-C 1 -C 6 alkylamine;

each R 2 is independently selected from the group consisting of halogen, a substituted or unsubstituted C 1 -C 6 alkyl, a substituted or unsubstituted C 1 -C 6 haloalkyl and a substituted or unsubstituted C 3 -C 6 cycloalkyl; or

when m is 2 or 3, each R 2 is independently selected from the group consisting of halogen, a substituted or unsubstituted C 1 -C 6 alkyl, a substituted or unsubstituted C 1 -C 6 haloalkyl and a substituted or unsubstituted C 3 -C 6 cycloalkyl, or two R 2 groups taken together with the atom(s) to which they are attached form a substituted or unsubstituted C 3 -C 6 cycloalkyl or a substituted or unsubstituted 3 to 6 membered heterocyclyl;

R 3 is selected from the group consisting of X—R 3A ,

R 3A is a substituted or unsubstituted 5 to 10 membered heteroaryl;

R 4 is selected from the group consisting of NO 2 , S(O)R 6 , SO 2 R 6 , halogen, cyano and an unsubstituted C 1 -C 6 haloalkyl;

R 5 is selected from the group consisting of —X 1 -(Alk 1 ) n -R 7 and —X 2 (CHR 8 )-(Alk 2 ) p -X 3 —R 9 ;

Alk 1 and Alk 2 are independently selected from an unsubstituted C 1 -C 4 alkylene and a C 1 -C 4 alkylene substituted with 1, 2 or 3 substituents independently selected from fluoro, chloro, an unsubstituted C 1 -C 3 alkyl and an unsubstituted C 1 -C 3 haloalkyl;

R 6 is selected from the group consisting of a substituted or unsubstituted C 1 -C 6 alkyl, a substituted or unsubstituted C 1 -C 6 haloalkyl and a substituted or unsubstituted C 3 -C 6 cycloalkyl;

R 7 is selected from a substituted or unsubstituted C 1 -C 6 alkoxy, a substituted or unsubstituted C 3 -C 10 cycloalkyl, a substituted or unsubstituted 3 to 10 membered heterocyclyl, hydroxy, amino, a substituted or unsubstituted mono-substituted amine group, a substituted or unsubstituted di-substituted amine group, a substituted or unsubstituted N-carbamyl, a substituted or unsubstituted C-amido and a substituted or unsubstituted N-amido;

R 8 is selected from a substituted or unsubstituted 3 to 10 membered heterocyclyl(C 1 -C 6 alkyl), a substituted or unsubstituted di-C 1 -C 6 alkylamine(C 1 -C 6 alkyl) and a substituted or unsubstituted mono-C 1 -C 6 alkylamine(C 1 -C 6 alkyl);

R 9 is selected from a substituted or unsubstituted 5 to 10 membered heteroaryl and a substituted or unsubstituted C 6 -C 10 aryl;

m is 0, 1, 2 or 3;

n and p are independently selected from 0 and 1;

X 1 and X 2 are —O—; and

X and X 3 are independently selected from the group consisting of —O—, —S— and —NH—.

2. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 1 is halogen.

3. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 1 is fluoro.

4. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 1 is chloro.

5. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 1 is a substituted or unsubstituted C 1 -C 6 alkyl.

6. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 1 is an unsubstituted C 1 -C 6 alkyl.

7. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 1 is an unsubstituted methyl or an unsubstituted ethyl.

8. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 1 is a substituted or unsubstituted C 1 -C 6 haloalkyl.

9. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 1 is an unsubstituted —CHF 2 , —CF 3 , —CH 2 CF 3 or —CF 2 CH 3 .

10. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 1 is hydrogen.

11. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 1 is a substituted or unsubstituted C 3 -C 6 cycloalkyl.

12. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 1 is an unsubstituted C 3 -C 6 cycloalkyl.

13. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 1 is a substituted or unsubstituted C 1 -C 6 alkoxy.

14. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 1 is an unsubstituted C 1 -C 6 alkoxy.

15. The compound of any one of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 1 is an unsubstituted methoxy or an unsubstituted ethoxy.

16. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 1 is an unsubstituted mono-C 1 -C 6 alkylamine.

17. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 1 is methylamine or ethylamine.

18. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 1 is an unsubstituted di-C 1 -C 6 alkylamine.

19. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 1 is di-methylamine or di-ethylamine.

20. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein m is 1.

21. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein m is 2.

22. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein m is 3.

23. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein one R 2 is an unsubstituted C 1 -C 6 alkyl and any other R 2 , if present, is independently selected from the group consisting of halogen, a substituted or unsubstituted C 1 -C 6 alkyl, a substituted or unsubstituted C 1 -C 6 haloalkyl and a substituted or unsubstituted C 3 -C 6 cycloalkyl.

24. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein each R 2 is independently an unsubstituted C 1 -C 6 alkyl.

25. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein m is 2; and each R 2 is an unsubstituted methyl.

26. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein m is 0.

27. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein two R 2 groups taken together with the atom(s) to which they are attached form a substituted or unsubstituted C 3 -C 6 cycloalkyl.

28. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein two R 2 groups taken together with the atom to which they are attached form an unsubstituted cyclopropyl.

29. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein two R 2 groups taken together with the atom(s) to which they are attached form a substituted or unsubstituted 3 to 6 membered heterocyclyl.

30. The compound of claim 1 , that is also a compound of Formula (Ia), Formula (Ib), Formula (Ic) or Formula (Id):

or pharmaceutically acceptable salts of any of the foregoing.

31. The compound of claim 1 , wherein R 3 is X—R 3A .

32. The compound of claim 1 , wherein

R 3A is

33. The compound of claim 1 , wherein

R 3A is

34. The compound of claim 1 , wherein R 3A is a substituted 5 to 10 membered heteroaryl.

35. The compound of claim 1 , wherein X is —O—.

36. The compound of claim 1 , wherein X is —S—.

37. The compound of claim 1 , wherein X is —NH—.

38. The compound of claim 1 , wherein

R 3 is

39. The compound of claim 1 , wherein

R 3 is

40. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 4 is NO 2 .

41. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 4 is cyano.

42. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 4 is halogen.

43. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 4 is an unsubstituted C 1 -C 6 haloalkyl.

44. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 4 is —CF 3 .

45. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 4 is S(O)R 6 .

46. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 4 is SO 2 R 6 .

47. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 6 is a substituted or unsubstituted C 1 -C 6 alkyl.

48. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 6 is a substituted or unsubstituted C 3 -C 6 cycloalkyl.

49. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 6 is a substituted or unsubstituted C 1 -C 6 haloalkyl.

50. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 6 is —CF 3 .

51. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 5 is —X 1 -(Alk 1 ) n -R 7 .

52. The compound of claim 51 , or a pharmaceutically acceptable salt thereof, wherein Alk 1 is unsubstituted —(CH 2 ) 1-4 —* for which “*” represents the point of attachment to R 7 .

53. The compound of claim 51 , or a pharmaceutically acceptable salt thereof, wherein Alk 1 is selected from

54. The compound of claim 51 , or a pharmaceutically acceptable salt thereof, wherein Alk 1 is a substituted

for which “*” represents the point of attachment to R 7 .

55. The compound of claim 51 , or a pharmaceutically acceptable salt thereof, wherein Alk 1 is selected from:

56. The compound of claim 51 , or a pharmaceutically acceptable salt thereof, wherein n is 1.

57. The compound of claim 51 , or a pharmaceutically acceptable salt thereof, wherein n is 0.

58. The compound of claim 51 , or a pharmaceutically acceptable salt thereof, wherein R 7 is a substituted or unsubstituted mono-substituted amine group.

59. The compound of claim 51 , or a pharmaceutically acceptable salt thereof, wherein R 7 is a substituted or unsubstituted di-substituted amine group.

60. The compound of claim 51 , or a pharmaceutically acceptable salt thereof, wherein R 7 is selected from a substituted or unsubstituted N-carbamyl, a substituted or unsubstituted C-amido and a substituted or unsubstituted N-amido.

61. The compound of claim 51 , or a pharmaceutically acceptable salt thereof, wherein R 7 is a substituted or unsubstituted C 3 -C 10 cycloalkyl.

62. The compound of claim 51 , or a pharmaceutically acceptable salt thereof, wherein R 7 is a substituted or unsubstituted C 6 -C 10 spirocycloalkyl.

63. The compound of claim 51 , or a pharmaceutically acceptable salt thereof, wherein R 7 is a substituted or unsubstituted 3 to 10 membered heterocyclyl.

64. The compound of claim 51 , or a pharmaceutically acceptable salt thereof, wherein R 7 is a substituted or unsubstituted 6 to 10 membered spiro heterocyclyl.

65. The compound of claim 51 , or a pharmaceutically acceptable salt thereof, wherein R 7 is hydroxy or amino.

66. The compound of claim 51 , or a pharmaceutically acceptable salt thereof, wherein R 7 is unsubstituted.

67. The compound of claim 51 , or a pharmaceutically acceptable salt thereof, wherein R 7 is substituted.

68. The compound of claim 51 , or a pharmaceutically acceptable salt thereof, wherein R 7 is substituted with 1 or 2 substituents independently selected from an unsubstituted C 1 -C 6 alkyl, an unsubstituted C 1 -C 6 alkoxy, fluoro, chloro, hydroxy and —SO 2 -(unsubstituted C 1 -C 6 alkyl).

69. The compound of claim 51 , or a pharmaceutically acceptable salt thereof, wherein R 7 is selected from:

70. The compound of claim 51 , or a pharmaceutically acceptable salt thereof, wherein R 7 is selected from:

71. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 5 is —X 2 —(CHR 8 )-(Alk 2 ) p -X 3 -R 9 .

72. The compound of claim 71 , or a pharmaceutically acceptable salt thereof, wherein X 3 is —O—.

73. The compound of claim 71 , or a pharmaceutically acceptable salt thereof, wherein X 3 is —S—.

74. The compound of claim 71 , or a pharmaceutically acceptable salt thereof, wherein X 3 is —NH—.

75. The compound of claim 71 , or a pharmaceutically acceptable salt thereof, wherein Alk 2 is unsubstituted —(CH 2 ) 1-4 —* for which “*” represents the point of attachment to X 3 .

76. The compound of claim 71 , or a pharmaceutically acceptable salt thereof, wherein Alk 2 is selected from

77. The compound of claim 71 , or a pharmaceutically acceptable salt thereof, wherein Alk 2 is a substituted

for which “*” represents the point of attachment to X 3 .

78. The compound of claim 71 , or a pharmaceutically acceptable salt thereof, wherein Alk 2 is selected from:

79. The compound of claim 71 , or a pharmaceutically acceptable salt thereof, wherein p is 1.

80. The compound of claim 71 , or a pharmaceutically acceptable salt thereof, wherein p is 0.

81. The compound of claim 71 , or a pharmaceutically acceptable salt thereof, wherein R 8 is a substituted or unsubstituted 3 to 10 membered heterocyclyl(C 1 -C 6 alkyl).

82. The compound of claim 71 , or a pharmaceutically acceptable salt thereof, wherein R 8 is a substituted or unsubstituted 6 to 10 membered spiro heterocyclyl(C 1 -C 6 alkyl).

83. The compound of claim 71 , or a pharmaceutically acceptable salt thereof, wherein R 8 is a substituted or unsubstituted di-C 1 -C 6 alkylamine(C 1 -C 6 alkyl).

84. The compound of claim 71 , or a pharmaceutically acceptable salt thereof, wherein R 8 is a substituted or unsubstituted di-methylamine(C 1 -C 6 alkyl).

85. The compound of claim 71 , or a pharmaceutically acceptable salt thereof, wherein R 8 is a substituted or unsubstituted mono-C 1 -C 6 alkylamine(C 1 -C 6 alkyl).

86. The compound of claim 71 , or a pharmaceutically acceptable salt thereof, wherein R 8 is substituted.

87. The compound of claim 71 , or a pharmaceutically acceptable salt thereof, wherein R 8 is substituted with 1 or 2 substituents independently selected from an unsubstituted C 1 -C 6 alkyl, an unsubstituted C 1 -C 6 alkoxy, an unsubstituted di-C 1 -C 6 alkylamine, an unsubstituted acyl(C 1 -C 6 alkyl), an unsubstituted C-carboxy, fluoro, chloro and hydroxy.

88. The compound of claim 71 , or a pharmaceutically acceptable salt thereof, wherein R 8 is unsubstituted.

89. The compound of claim 71 , or a pharmaceutically acceptable salt thereof, wherein R 8 is selected from:

90. The compound of claim 71 , or a pharmaceutically acceptable salt thereof, wherein R 8 is selected from:

91. The compound of claim 71 , or a pharmaceutically acceptable salt thereof, wherein R 9 is a substituted or unsubstituted C 6 -C 10 aryl.

92. The compound of claim 71 , or a pharmaceutically acceptable salt thereof, wherein R 9 is an unsubstituted C 6 -C 10 aryl.

93. The compound of claim 71 , or a pharmaceutically acceptable salt thereof, wherein R 9 is an unsubstituted phenyl.

94. The compound of claim 71 , or a pharmaceutically acceptable salt thereof, wherein R 9 is a substituted or unsubstituted 5 to 10 membered heteroaryl.

95. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein the compound is selected from the group consisting of:

96. The compound of claim 95 , wherein the compound is selected from the group consisting of:

or a pharmaceutically acceptable salt of any of the foregoing.

97. A pharmaceutical composition comprising an effective amount of the compound of claim 1 , or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, diluent, excipient or combination thereof.