Serpin production

1. A method for treatment of inflammatory bowel disease, celiac disease, non-celiac gluten sensitivity, gluten ataxia, dermatitis herpetiformis or wheat allergy in a subject in need thereof, the method comprising administering to the subject a composition comprising B. longum strain CNCM I-2618 and 0.03 to 0.40 wt % of a sugar selected from the group consisting of lactose, fructose, raffinose, and combinations thereof.

2. The method of claim 1 , wherein the B. Longum strain CNCM I-2618 and the sugar are administered simultaneously or sequentially.

3. The method of claim 1 , wherein the B. Longum strain CNCM I-2618 and the sugar are coformulated.

4. The method of claim 1 , wherein the B. Longum strain CNCM I-2618 and the sugar are provided in separate compositions.

5. The method of claim 1 , wherein the composition is adminstered enterally.

6. The method of claim 1 , wherein the subject is selected from the group consisting of human, canine, feline, equine, caprine, bovine, ovine, porcine, cervine, and primate.

7. The method of claim 1 , wherein the B. Longum strain CNM I-2618 is produced by growing the B. Longum strain CNM I-2618 in a culture medium comprising the sugar.

8. The method of claim 7 , wherein the culture medium comprises the sugar at a concentration of 0.02 to 0.5 wt %.

9. The method of claim 7 , wherein the culture medium comprises the sugar at a concentration of 0.05 to 0.15 wt %.

10. The method of claim 7 , wherin the the sugar in the culture medium comprises lactose.

11. The method of claim 1 , wherein the sugar comprises lactose.

12. The method of claim 1 , wherein the composition comprises 0.04 to 0.30 wt % of the sugar.

13. The method of claim 1 , wherein the composition comprises 0.05 to 0.20 wt % of the sugar.

14. The method of claim 7 , wherein the culture medium comprises 0.04 to 0.30 wt % of the sugar.

15. The method of claim 7 , wherein the culture medium comprises 0.05 to 0.20 wt % of the sugar.