Microneedle for local delivery of therapeutic agent
The disclosed subject matter relates to a cleavable microneedle for delivery of therapeutic agent, wherein the needle includes a longitudinal body having a detachable portion that comprises at least one therapeutic agent. The microneedle may be configured to administer the therapeutic agent to the inner ear of a subject. Also disclosed is a method for preparing a microneedle using two-photon polymerization lithography.
1. A medical device comprising;
a single microneedle comprising a longitudinal body having a maximum diameter from about 10 to about 150 microns and a detachable distal portion comprising a therapeutic agent; and
a single tubular member coupled to a proximal end of the single microneedle, the tubular member capable of advancing the microneedle through an anatomic barrier.
2. The medical device of claim 1 wherein the anatomic barrier is a round window membrane of an inner ear.
3. The medical device of claim 1 , wherein the single microneedle comprising a pinched region to facilitate cleavage of the detachable portion.
4. The medical device of claim 1 , wherein the longitudinal body is hollow or solid.
5. The medical device of claim 1 , wherein the microneedle comprises a tip having a tip radius of curvature of about 0.3 to 0.7 microns.
6. The medical device of claim 1 , wherein the microneedle comprises a tip having a tip radius of curvature of about 2.5 to 3 microns.
7. The medical device of claim 1 , wherein the tubular member is a syringe tip.
8. A medical device comprising;
a single microneedle comprising a hollow longitudinal body having a maximum diameter from about 10 to about 150 microns and a detachable distal portion comprising a therapeutic agent, the distal portion having a tapered portion; and
a single tubular member defining a lumen and coupled to a proximal end of the single microneedle, the tubular member connected to a reservoir for carrying a therapeutic agent for delivery through the lumen in the tubular member and the hollow longitudinal body of the microneedle, the tubular member capable of advancing the microneedle through an anatomic barrier.
9. The medical device of claim 8 wherein the anatomic barrier is a round window membrane of an inner ear.
10. The medical device of claim 8 , the single microneedle comprising a pinched region to facilitate cleavage of the detachable portion.
11. The medical device of claim 8 , wherein the longitudinal body comprises silicon or tungsten.
12. The medical device of claim 8 , wherein the longitudinal body is configured with a taper along at least a portion of a length of the longitudinal body.
13. The medical device of claim 8 , wherein the single microneedle comprises a pinched region to facilitate cleavage of the detachable portion.
14. The medical device of claim 8 , wherein the tubular member is a syringe tip.
15. A medical device comprising;
a single microneedle comprising a hollow longitudinal body having a maximum diameter from about 10 to about 150 microns and a detachable distal portion comprising a therapeutic agent, the distal portion having a tapered portion defining a taper of about 9 degrees, the single microneedle comprising a pinched region to facilitate cleavage of the detachable portion; and
a single tubular member defining a lumen and coupled to a proximal end of the single microneedle, the tubular member connected to a reservoir for carrying a therapeutic agent for delivery through the lumen in the tubular member and the hollow longitudinal body of the microneedle, the tubular member capable of advancing the microneedle through an anatomic barrier.
16. The medical device of claim 15 wherein the anatomic barrier is a round window membrane of an inner ear.
17. The medical device of claim 15 , wherein the longitudinal body comprises silicon or tungsten.
18. The medical device of claim 15 , wherein the tubular member is a syringe tip.
19. The medical device of claim 18 , wherein the tubular member is a gauge 23 syringe tip.