Granted Patent
B2
US 11,597,743 · App. 16/960,608 · Granted Mar 7, 2023
Glycosyltransferase inhibitors for treatment of solid tumors
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Abstract
The present invention relates to methods of treating bacterial infections and cancer in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a compound of Formula I. Also provided are methods of inhibiting dolichyl-phosphate N-acetylglucosaminephosphotransferase (DPAGT1) in an individual in need thereof, comprising administering to the individual a therapeutically effective amount of a compound of Formula I:
Claims (3)
1. A compound that is
or a pharmaceutically acceptable salt thereof.
2. A pharmaceutical composition comprising the compound according to claim 1 , or a pharmaceutically acceptable salt thereof, and at least one pharmaceutically acceptable carrier.
Assignments (3)
CONFIRMATORY LICENSE
Recorded Oct 13, 2023
From: CALIFORNIA INSTITUTE OF TECHNOLOGY
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 065215/0886 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Nov 23, 2020
From: . CLEMONS, WILLIAM M
To: CALIFORNIA INSTITUTE OF TECHNOLOGY
Reel/Frame 054443/0285 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Nov 20, 2020
From: KUROSU, MICHIO
To: UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION
Reel/Frame 054432/0542 →
Continuity (2)
Provisional Application
62616657
· Jan 12, 2018