IP Library › Granted Patent US 12,247,060
Granted Patent B2
US 12,247,060 · App. 16/960,704 · Granted Mar 11, 2025

Calreticulin binding constructs and engineered T cells for the treatment of diseases

Inventors: Andreas Loew (Cambridge, MA); Brian Edward Vash (Cambridge, MA)
Assignee: Marengo Therapeutics, Inc.
C07K14/7051A61K35/17A61K39/4611A61K39/4631A61K39/4644C07K14/70521C07K14/70578C07K16/18C07K16/28C07K2317/565C07K2317/92C07K2319/03
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Quick Facts
Patent No.
US 12,247,060
App. No.
16/960,704
Granted
Mar 11, 2025
Kind
B2
Abstract

Provided herein are nucleic acid constructs, polypeptides and T cells related to antigen binding domains that bind to mutant calreticulin; and methods of use thereof for the treatment of diseases, including cancer.

Claims (36)

1. A composition comprising a nucleic acid comprising a sequence encoding a chimeric antigen receptor (CAR), wherein the CAR comprises an antibody domain comprising a mutant calreticulin binding domain, a transmembrane domain, and an intracellular domain comprising an intracellular signaling domain;

wherein the mutant calreticulin binding domain comprises a heavy chain variable domain (VH) comprising an amino acid sequence with at least 77% sequence identity to SEQ ID NO: 1 or an amino acid sequence with at least 75% sequence identity to SEQ ID NO: 2 and a light chain variable domain (VL), wherein:

(I) the VH comprises a heavy chain complement determining region 1 (HC CDR1) with the amino acid sequence of SEQ ID NO: 7, a HC CDR2 with the amino acid sequence of SEQ ID NO: 8, and a HC CDR3 with the amino acid sequence of SEQ ID NO: 9; and the VL comprises a light chain CDR1 (LC CDR1) with the amino acid sequence of SEQ ID NO: 13, a LC CDR2 with the amino acid sequence of SEQ ID NO: 14, and a LC CDR3 with the amino acid sequence of SEQ ID NO: 15;

(II) the VH comprises a HC CDR1 with the amino acid sequence of SEQ ID NO: 10, a HC CDR2 with the amino acid sequence of SEQ ID NO: 11, and a HC CDR3 with the amino acid sequence of SEQ ID NO: 12; and the VL comprises a LC CDR1 with the amino acid sequence of SEQ ID NO: 13, a LC CDR2 with the amino acid sequence of SEQ ID NO: 14, and a LC CDR3 with the amino acid sequence of SEQ ID NO: 15; or

(III) the VH comprises a HC CDR1 with the amino acid sequence of SEQ ID NO: 10, a HC CDR2 with the amino acid sequence of SEQ ID NO: 11, and a HC CDR3 with the amino acid sequence of SEQ ID NO: 16; and the VL comprises a LC CDR1 with the amino acid sequence of SEQ ID NO: 13, a LC CDR2 with the amino acid sequence of SEQ ID NO: 14, and a LC CDR3 with the amino acid sequence of SEQ ID NO: 15.

2. The composition of claim 1 , wherein the mutant calreticulin binding domain comprises:

(a) a HC CDR1 with the amino acid sequence of SEQ ID NO: 7, a HC CDR2 with the amino acid sequence of SEQ ID NO: 8, and a HC CDR3 with the amino acid sequence of SEQ ID NO: 9; and

(b) a LC CDR1 with the amino acid sequence of SEQ ID NO: 13, a LC CDR2 with the amino acid sequence of SEQ ID NO: 14, and a LC CDR3 with the amino acid sequence of SEQ ID NO: 15.

3. The composition of claim 1 , wherein the mutant calreticulin binding domain comprises:

(a) a HC CDR1 with an amino acid sequence of SEQ ID NO: 10, a HC CDR2 with an amino acid sequence of SEQ ID NO: 11, and a HC CDR3 with an amino acid sequence of SEQ ID NO: 12; and

(b) a LC CDR1 with an amino acid sequence of SEQ ID NO: 13, a LC CDR2 with an amino acid sequence of SEQ ID NO: 14, and a LC CDR3 with an amino acid sequence of SEQ ID NO: 15.

4. The composition of claim 1 , wherein the mutant calreticulin binding domain comprises:

(a) a HC CDR1 with an amino acid sequence of SEQ ID NO: 10, a HC CDR2 with an amino acid sequence of SEQ ID NO: 11, and a HC CDR3 with an amino acid sequence of SEQ ID NO: 16; and

(b) a LC CDR1 with an amino acid sequence of SEQ ID NO: 13, a LC CDR2 with an amino acid sequence of SEQ ID NO: 14, and a LC CDR3 with an amino acid sequence of SEQ ID NO: 15.

5. The composition of claim 1 , wherein the VL comprises an amino acid sequence with at least 93% sequence identity to SEQ ID NO: 3.

6. The composition of claim 1 , wherein the VH comprises an amino acid sequence with at least 75% sequence identity to SEQ ID NO: 2.

7. The composition of claim 6 , wherein the VL comprises an amino acid sequence with at least 93% sequence identity to SEQ ID NO: 3.

8. The composition of claim 1 , wherein the VH comprises an amino acid sequence with at least 90% sequence identity to SEQ ID NO: 1 and the VL comprises an amino acid sequence with at least 90% sequence identity to SEQ ID NO: 3.

9. The composition of claim 1 , wherein the VH comprises an amino acid sequence with at least 90% sequence identity to SEQ ID NO: 2 and the VL comprises an amino acid sequence with at least 90% sequence identity to SEQ ID NO: 3.

10. The composition of claim 1 , wherein the VH comprises an amino acid sequence with at least 95% sequence identity to SEQ ID NO: 1 and the VL comprises an amino acid sequence with at least 95% sequence identity to SEQ ID NO: 3.

11. The composition of claim 1 , wherein the VH comprises an amino acid sequence with at least 95% sequence identity to SEQ ID NO: 2 and the VL comprises an amino acid sequence with at least 95% sequence identity to SEQ ID NO: 3.

12. The composition of claim 1 , wherein the antibody domain is a human or humanized antibody domain.

13. The composition of claim 1 , wherein the mutant calreticulin binding domain binds to an epitope of a mutant calreticulin polypeptide with K D of 200 nM or less.

14. The composition of claim 1 , wherein the nucleic acid further includes a sequence that encodes a leader sequence.

15. The composition of claim 1 , wherein the antibody domain is connected to the transmembrane domain by a hinge domain.

16. The composition of claim 15 , wherein the hinge domain comprises a CD8 amino acid sequence or an IgG4 amino acid sequence.

17. The composition of claim 1 , wherein the transmembrane domain comprises a transmembrane domain of a protein selected from the group consisting of a T-cell receptor alpha chain, a T-cell receptor beta chain, a T-cell receptor zeta chain, CD28, CD3 epsilon, CD45, CD4, CDS, CD8, CD9, CD16, CD22, CD33, CD37, CD64, CD80, CD86, CD134, 4-1BB (CD137), and CD154.

18. The composition of claim 1 , wherein the intracellular signaling domain comprises a costimulatory domain, wherein the costimulatory domain comprises a functional signaling domain derived from a protein selected from the group consisting of a MHC class I molecule, a TNF receptor protein, an Immunoglobulin-like protein, a cytokine receptor, an integrin, a signaling lymphocytic activation molecule (SLAM protein), an activating NK cell receptor, BTLA, a Toll ligand receptor, OX40, CD2, CD7, CD27, CD28, CD30, CD40, CDS, ICAM-1, LFA-1 (CD1la/CD18), 4-1BB (CD137), B7-H3, ICOS (CD278), GITR, BAFFR, LIGHT, HVEM (LIGHTR), KIRDS2, SLAMF7, NKp80 (KLRF1), NKp44, NKp30, NKp46, CD19, CD4, CD8alpha, CD8beta, IL2R beta, IL2R gamma, IL7R alpha, ITGA4, VLA1, CD49a, IA4, CD49D, ITGA6, VLA-6, CD49f, ITGAD, CD11d, ITGAE, CD 103, ITGAL, ITGAM, CD11b, ITGAX, CD11c, ITGB1, CD29, ITGB2, ITGB7, NKG2D, NKG2C, TNFR2, TRANCE/RANKL, DNAM1 (CD226), SLAMF4 (CD244, 2B4), CD84, CD96 (Tactile), CEACAMI, CRTAM, Ly9 (CD229), CD160 (BY55), PSGL1, CD100 (SEMA4D), CD69, SLAMF6 (NTB-A, Ly108), SLAM (SLAMFI, CD150, IPO-3), BLAME (SLAMF8), SELPLG (CD162), LTBR, LAT, GADS, SLP-76, PAG/Cbp, CD19a, and a ligand that specifically binds with CD83.

19. The composition of claim 18 , wherein the costimulatory domain comprises a 4-1BB (CD137) amino acid sequence, or a CD28 amino acid sequence, or an ICOS (CD278) amino acid sequence.

20. The composition of claim 1 , wherein the intracellular signaling domain comprises a CD3 zeta amino acid sequence.

21. The composition of claim 1 , wherein the intracellular signaling domain comprises a functional signaling domain of 4-1BB (CD137) or a functional signaling domain of CD3 zeta.

22. The composition of claim 1 , wherein the intracellular signaling domain comprises a primary signaling domain comprising a functional signaling domain derived from CD3 zeta, TCR zeta, FcR gamma, FcR beta, CD3 gamma, CD3 delta, CD3 epsilon, CDS, CD22, CD79a, CD79b, CD278, FcεRI, DAP10, DAP12, or CD66d.

23. A composition comprising a cell comprising the composition of claim 1 .

24. A pharmaceutical composition comprising

(i) the cell of claim 23 ; and

(ii) a pharmaceutically acceptable carrier, diluent or excipient.

Assignments (2)
CHANGE OF NAME Recorded Sep 6, 2022
From: ELSTAR THERAPEUTICS, INC.
To: MARENGO THERAPEUTICS, INC.
Reel/Frame 061386/0079 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 15, 2021
From: LOEW, ANDREAS; VASH, BRIAN EDWARD
To: ELSTAR THERAPEUTICS, INC.
Reel/Frame 055590/0745 →
Continuity (2)
Provisional Application 62615270 · Jan 9, 2018
Related Publication 20210137982A1 · May 13, 2021
References Cited (400)
US 861745A · Maxwell · 1907 [cited by applicant]
US 4433059A · Chang et al. · 1984 [cited by applicant]
US 4439196A · Higuchi · 1984 [cited by applicant]
US 4444878A · Paulus · 1984 [cited by applicant]
US 4447224A · DeCant, Jr. et al. · 1984 [cited by applicant]
US 4447233A · Mayfield · 1984 [cited by applicant]
US 4475196A · La Zor · 1984 [cited by applicant]
US 4486194A · Ferrara · 1984 [cited by applicant]
US 4487603A · Harris · 1984 [cited by applicant]
US 4522811A · Eppstein et al. · 1985 [cited by applicant]
US 4596556A · Morrow et al. · 1986 [cited by applicant]
US 4676980A · Segal et al. · 1987 [cited by applicant]
US 4737456A · Weng et al. · 1988 [cited by applicant]
US 4790824A · Morrow et al. · 1988 [cited by applicant]
US 4816567A · Cabilly et al. · 1989 [cited by applicant]
US 4941880A · Burns · 1990 [cited by applicant]
US 5057423A · Hiserodt et al. · 1991 [cited by applicant]
US 5064413A · McKinnon et al. · 1991 [cited by applicant]
US 5116615A · Gokcen et al. · 1992 [cited by applicant]
US 5208020A · Chari et al. · 1993 [cited by applicant]
US 5223409A · Ladner et al. · 1993 [cited by applicant]
US 5225539A · Winter · 1993 [cited by applicant]
US 5273743A · Ahlem et al. · 1993 [cited by applicant]
US 5312335A · McKinnon et al. · 1994 [cited by applicant]
US 5374548A · Caras · 1994 [cited by applicant]
US 5383851A · McKinnon, Jr. et al. · 1995 [cited by applicant]
US 5391377A · Barnwell · 1995 [cited by applicant]
US 5399163A · Peterson et al. · 1995 [cited by applicant]
US 5399331A · Loughrey et al. · 1995 [cited by applicant]
US 5416016A · Low et al. · 1995 [cited by applicant]
US 5416064A · Chari et al. · 1995 [cited by applicant]
US 5500362A · Robinson et al. · 1996 [cited by applicant]
US 5534254A · Huston et al. · 1996 [cited by applicant]
US 5571894A · Wels et al. · 1996 [cited by applicant]
US 5582996A · Curtis · 1996 [cited by applicant]
US 5585089A · Queen et al. · 1996 [cited by applicant]
US 5587458A · King et al. · 1996 [cited by applicant]
US 5591828A · Bosslet et al. · 1997 [cited by applicant]
US 5624821A · Winter et al. · 1997 [cited by applicant]
US 5626561A · Butler et al. · 1997 [cited by applicant]
US 5635483A · Pettit et al. · 1997 [cited by applicant]
US 5635602A · Cantor et al. · 1997 [cited by applicant]
US 5637481A · Ledbetter et al. · 1997 [cited by applicant]
US 5641870A · Rinderknecht et al. · 1997 [cited by applicant]
US 5648237A · Carter · 1997 [cited by applicant]
US 5648260A · Winter et al. · 1997 [cited by applicant]
US 5693761A · Queen et al. · 1997 [cited by applicant]
US 5693762A · Queen et al. · 1997 [cited by applicant]
US 5712374A · Kuntsmann et al. · 1998 [cited by applicant]
US 5714586A · Kunstmann et al. · 1998 [cited by applicant]
US 5731116A · Matsuo et al. · 1998 [cited by applicant]
US 5731168A · Carter et al. · 1998 [cited by applicant]
US 5739116A · Hamann et al. · 1998 [cited by applicant]
US 5747036A · Brenner et al. · 1998 [cited by applicant]
US 5750373A · Garrard et al. · 1998 [cited by applicant]
US 5766947A · Rittershaus et al. · 1998 [cited by applicant]
US 5767285A · Hamann et al. · 1998 [cited by applicant]
US 5770429A · Lonberg et al. · 1998 [cited by applicant]
US 5770701A · McGahren et al. · 1998 [cited by applicant]
US 5770710A · McGahren et al. · 1998 [cited by applicant]
US 5773001A · Hamann et al. · 1998 [cited by applicant]
US 5780588A · Pettit et al. · 1998 [cited by applicant]
US 5787900A · Butler et al. · 1998 [cited by applicant]
US 5789199A · Joly et al. · 1998 [cited by applicant]
US 5811097A · Allison et al. · 1998 [cited by applicant]
US 5821337A · Carter et al. · 1998 [cited by applicant]
US 5831012A · Nilsson et al. · 1998 [cited by applicant]
US 5837242A · Holliger et al. · 1998 [cited by applicant]
US 5837821A · Wu · 1998 [cited by applicant]
US 5840523A · Simmons et al. · 1998 [cited by applicant]
US 5843069A · Butler et al. · 1998 [cited by applicant]
US 5844094A · Hudson et al. · 1998 [cited by applicant]
US 5849500A · Breitling et al. · 1998 [cited by applicant]
US 5849589A · Tedder et al. · 1998 [cited by applicant]
US 5861155A · Lin · 1999 [cited by applicant]
US 5864019A · King et al. · 1999 [cited by applicant]
US 5869046A · Presta et al. · 1999 [cited by applicant]
US 5869620A · Whitlow et al. · 1999 [cited by applicant]
US 5877296A · Hamann et al. · 1999 [cited by applicant]
US 5902745A · Butler et al. · 1999 [cited by applicant]
US 5910573A · Plueckthun et al. · 1999 [cited by applicant]
US 5913998A · Butler et al. · 1999 [cited by applicant]
US 5932448A · Tso et al. · 1999 [cited by applicant]
US 5959083A · Bosslet et al. · 1999 [cited by applicant]
US 5959177A · Hein et al. · 1999 [cited by applicant]
US 5968753A · Tseng-Law et al. · 1999 [cited by applicant]
US 5980889A · Butler et al. · 1999 [cited by applicant]
US 5989830A · Davis et al. · 1999 [cited by applicant]
US 6005079A · Casterman et al. · 1999 [cited by applicant]
US 6040498A · Stomp et al. · 2000 [cited by applicant]
US 6075181A · Kucherlapati et al. · 2000 [cited by applicant]
US 6120766A · Hale et al. · 2000 [cited by applicant]
US 6150584A · Kucherlapati et al. · 2000 [cited by applicant]
US 6171586B1 · Lam et al. · 2001 [cited by applicant]
US 6172197B1 · McCafferty et al. · 2001 [cited by applicant]
US 6194551B1 · Idusogie et al. · 2001 [cited by applicant]
US 6239259B1 · Davis et al. · 2001 [cited by applicant]
US 6248516B1 · Winter et al. · 2001 [cited by applicant]
US 6267958B1 · Andya et al. · 2001 [cited by applicant]
US 6291158B1 · Winter et al. · 2001 [cited by applicant]
US 6294353B1 · Pack et al. · 2001 [cited by applicant]
US 6333396B1 · Filpula et al. · 2001 [cited by applicant]
US 6352694B1 · June et al. · 2002 [cited by applicant]
US 6417429B1 · Hein et al. · 2002 [cited by applicant]
US 6420548B1 · Vezina et al. · 2002 [cited by applicant]
US 6476198B1 · Kang · 2002 [cited by applicant]
US 6511663B1 · King et al. · 2003 [cited by applicant]
US 6534055B1 · June et al. · 2003 [cited by applicant]
US 6582915B1 · Griffiths et al. · 2003 [cited by applicant]
US 6593081B1 · Griffiths et al. · 2003 [cited by applicant]
US 6602684B1 · Umana et al. · 2003 [cited by applicant]
US 6630579B2 · Chari et al. · 2003 [cited by applicant]
US 6632427B1 · Finiels et al. · 2003 [cited by applicant]
US 6670453B2 · Frenken et al. · 2003 [cited by applicant]
US 6696245B2 · Winter et al. · 2004 [cited by applicant]
US 6703199B1 · Koide · 2004 [cited by applicant]
US 6737056B1 · Presta · 2004 [cited by applicant]
US 6743896B2 · Filpula et al. · 2004 [cited by applicant]
US 6756523B1 · Kahn et al. · 2004 [cited by applicant]
US 6765087B1 · Casterman et al. · 2004 [cited by applicant]
US 6809185B1 · Schoonjans et al. · 2004 [cited by applicant]
US 6818418B1 · Lipovsek et al. · 2004 [cited by applicant]
US 6833441B2 · Wang et al. · 2004 [cited by applicant]
US 6838254B1 · Hamers et al. · 2005 [cited by applicant]
US 6905680B2 · June et al. · 2005 [cited by applicant]
US 6979546B2 · Moretta et al. · 2005 [cited by applicant]
US 6982321B2 · Winter · 2006 [cited by applicant]
US 7041870B2 · Tomizuka et al. · 2006 [cited by applicant]
US 7083785B2 · Browning et al. · 2006 [cited by applicant]
US 7087409B2 · Barbas, III et al. · 2006 [cited by applicant]
US 7105149B1 · Dalla-Favera · 2006 [cited by applicant]
US 7125978B1 · Vezina et al. · 2006 [cited by applicant]
US 7129330B1 · Little et al. · 2006 [cited by applicant]
US 7183076B2 · Arathoon et al. · 2007 [cited by applicant]
US 7186804B2 · Gillies et al. · 2007 [cited by applicant]
US 7189826B2 · Rodman · 2007 [cited by applicant]
US 7250297B1 · Beste et al. · 2007 [cited by applicant]
US 7276241B2 · Schneider et al. · 2007 [cited by applicant]
US 7332581B2 · Presta · 2008 [cited by applicant]
US 7361360B2 · Kitabwalla et al. · 2008 [cited by applicant]
US 7371826B2 · Presta · 2008 [cited by applicant]
US 7402314B2 · Sherman · 2008 [cited by applicant]
US 7431380B1 · Buresh · 2008 [cited by applicant]
US 7476724B2 · Dennis et al. · 2009 [cited by applicant]
US 7498298B2 · Doronina et al. · 2009 [cited by applicant]
US 7501121B2 · Tchistiakova et al. · 2009 [cited by applicant]
US 7517966B2 · Moretta et al. · 2009 [cited by applicant]
US 7521056B2 · Chang et al. · 2009 [cited by applicant]
US 7521541B2 · Eigenbrot et al. · 2009 [cited by applicant]
US 7527787B2 · Chang et al. · 2009 [cited by applicant]
US 7527791B2 · Adams et al. · 2009 [cited by applicant]
US 7534866B2 · Chang et al. · 2009 [cited by applicant]
US 7563441B2 · Graus et al. · 2009 [cited by applicant]
US 7601803B1 · Fiedler et al. · 2009 [cited by applicant]
US 7612181B2 · Wu et al. · 2009 [cited by applicant]
US 7642228B2 · Carter et al. · 2010 [cited by applicant]
US 7700739B2 · Lacy et al. · 2010 [cited by applicant]
US 7741446B2 · Pardridge et al. · 2010 [cited by applicant]
US 7750128B2 · Gegg et al. · 2010 [cited by applicant]
US 7767429B2 · Bookbinder et al. · 2010 [cited by applicant]
US 7799902B2 · Browning et al. · 2010 [cited by applicant]
US 7803376B2 · Velardi et al. · 2010 [cited by applicant]
US 7807160B2 · Presta et al. · 2010 [cited by applicant]
US 7829289B2 · Lantz et al. · 2010 [cited by applicant]
US 7855275B2 · Eigenbrot et al. · 2010 [cited by applicant]
US 7858759B2 · Brandt et al. · 2010 [cited by applicant]
US 7906118B2 · Chang et al. · 2011 [cited by applicant]
US 7919257B2 · Hoogenboom et al. · 2011 [cited by applicant]
US 7943743B2 · Korman et al. · 2011 [cited by applicant]
US 7999077B2 · Pastan et al. · 2011 [cited by applicant]
US 8003774B2 · Stavenhagen et al. · 2011 [cited by applicant]
US 8008449B2 · Korman et al. · 2011 [cited by applicant]
US 8012465B2 · Elias et al. · 2011 [cited by applicant]
US 8034326B2 · Hjorth et al. · 2011 [cited by applicant]
US 8202517B2 · Bookbinder et al. · 2012 [cited by applicant]
US 8216805B2 · Carter et al. · 2012 [cited by applicant]
US 8299220B2 · Dalla-Favera · 2012 [cited by applicant]
US 8354509B2 · Carven et al. · 2013 [cited by applicant]
US 8362213B2 · Elkins et al. · 2013 [cited by applicant]
US 8450470B2 · Bookbinder et al. · 2013 [cited by applicant]
US 8466260B2 · Elkins et al. · 2013 [cited by applicant]
US 8552156B2 · Takayanagi et al. · 2013 [cited by applicant]
US 8580252B2 · Bookbinder et al. · 2013 [cited by applicant]
US 8586713B2 · Davis et al. · 2013 [cited by applicant]
US 8592562B2 · Kannan et al. · 2013 [cited by applicant]
US 8609089B2 · Langermann et al. · 2013 [cited by applicant]
US 8617545B2 · Hsu et al. · 2013 [cited by applicant]
US 8617559B2 · Elkins et al. · 2013 [cited by applicant]
US 8658135B2 · O'Connor-McCourt et al. · 2014 [cited by applicant]
US 8703132B2 · Imhof-Jung et al. · 2014 [cited by applicant]
US 8772246B2 · Bookbinder et al. · 2014 [cited by applicant]
US 8790895B2 · Fiedler et al. · 2014 [cited by applicant]
US 8821883B2 · Ambrose et al. · 2014 [cited by applicant]
US 8846042B2 · Zhou · 2014 [cited by applicant]
US 8871912B2 · Davis et al. · 2014 [cited by applicant]
US 8920776B2 · Gaiger et al. · 2014 [cited by applicant]
US 8945571B2 · Mössner et al. · 2015 [cited by applicant]
US 8993524B2 · Bedi et al. · 2015 [cited by applicant]
US 9000130B2 · Bhakta et al. · 2015 [cited by applicant]
US 9034324B2 · Kalled et al. · 2015 [cited by applicant]
US 9056905B2 · Olson et al. · 2015 [cited by applicant]
US 9145588B2 · Throsby et al. · 2015 [cited by applicant]
US 9200060B2 · Kannan et al. · 2015 [cited by applicant]
US 9243058B2 · Armitage et al. · 2016 [cited by applicant]
US 9309311B2 · Gurney et al. · 2016 [cited by applicant]
US 9340621B2 · Kufer et al. · 2016 [cited by applicant]
US 9358286B2 · De Kruif et al. · 2016 [cited by applicant]
US 9359437B2 · Davis et al. · 2016 [cited by applicant]
US 9382323B2 · Brinkmann et al. · 2016 [cited by applicant]
US 9387237B2 · Kalled et al. · 2016 [cited by applicant]
US 9416187B2 · Tedder et al. · 2016 [cited by applicant]
US 9447159B2 · Ast et al. · 2016 [cited by applicant]
US 9447185B2 · Romagne et al. · 2016 [cited by applicant]
US 9545086B2 · Mackay et al. · 2017 [cited by applicant]
US 9593376B2 · Zitvogel et al. · 2017 [cited by applicant]
US 9663577B2 · Pierres et al. · 2017 [cited by applicant]
US 9676863B2 · Lo · 2017 [cited by applicant]
US 9833476B2 · Zhang et al. · 2017 [cited by applicant]
US 10150816B2 · Abbot · 2018 [cited by examiner]
US 10294300B2 · Raum et al. · 2019 [cited by applicant]
US 10308721B2 · Williams et al. · 2019 [cited by applicant]
US 10478509B2 · Torgov et al. · 2019 [cited by applicant]
US 10610571B2 · Ptacin et al. · 2020 [cited by applicant]
US 10676516B2 · Viney et al. · 2020 [cited by applicant]
US 10730942B2 · Pule et al. · 2020 [cited by applicant]
US 10815311B2 · Wesche et al. · 2020 [cited by applicant]
US 11033634B2 · Stull et al. · 2021 [cited by applicant]
US 11291721B2 · Loew et al. · 2022 [cited by applicant]
US 11292838B2 · Schendel et al. · 2022 [cited by applicant]
US 11673953B2 · Zhang et al. · 2023 [cited by applicant]
US 11692031B2 · Dahlhoff et al. · 2023 [cited by applicant]
US 11845797B2 · Tan et al. · 2023 [cited by applicant]
US 11965025B2 · Tan et al. · 2024 [cited by applicant]
US 20020004587A1 · Miller et al. · 2002 [cited by applicant]
US 20020041865A1 · Austin et al. · 2002 [cited by applicant]
US 20020062010A1 · Arathoon et al. · 2002 [cited by applicant]
US 20020076406A1 · Leung · 2002 [cited by applicant]
US 20020103345A1 · Zhu · 2002 [cited by applicant]
US 20020164328A1 · Shinkawa et al. · 2002 [cited by applicant]
US 20030115614A1 · Kanda et al. · 2003 [cited by applicant]
US 20030130496A1 · Winter et al. · 2003 [cited by applicant]
US 20030157108A1 · Presta · 2003 [cited by applicant]
US 20030175884A1 · Umana et al. · 2003 [cited by applicant]
US 20030207346A1 · Arathoon et al. · 2003 [cited by applicant]
US 20030211078A1 · Heavner · 2003 [cited by applicant]
US 20040009530A1 · Wilson et al. · 2004 [cited by applicant]
US 20040093621A1 · Shitara et al. · 2004 [cited by applicant]
US 20040109865A1 · Niwa et al. · 2004 [cited by applicant]
US 20040110282A1 · Kanda et al. · 2004 [cited by applicant]
US 20040110704A1 · Yamane et al. · 2004 [cited by applicant]
US 20040132140A1 · Satoh et al. · 2004 [cited by applicant]
US 20040175756A1 · Kolkman et al. · 2004 [cited by applicant]
US 20040219643A1 · Winter et al. · 2004 [cited by applicant]
US 20040220388A1 · Mertens et al. · 2004 [cited by applicant]
US 20040241817A1 · Umana et al. · 2004 [cited by applicant]
US 20040242847A1 · Fukushima et al. · 2004 [cited by applicant]
US 20050003403A1 · Rossi et al. · 2005 [cited by applicant]
US 20050004352A1 · Kontermann et al. · 2005 [cited by applicant]
US 20050014934A1 · Hinton et al. · 2005 [cited by applicant]
US 20050048512A1 · Kolkman et al. · 2005 [cited by applicant]
US 20050053973A1 · Kolkman et al. · 2005 [cited by applicant]
US 20050069552A1 · Bleck et al. · 2005 [cited by applicant]
US 20050079170A1 · Le Gall et al. · 2005 [cited by applicant]
US 20050079574A1 · Bond · 2005 [cited by applicant]
US 20050090648A1 · Tsurushita et al. · 2005 [cited by applicant]
US 20050100543A1 · Hansen et al. · 2005 [cited by applicant]
US 20050119455A1 · Fuh et al. · 2005 [cited by applicant]
US 20050123546A1 · Umana et al. · 2005 [cited by applicant]
US 20050136049A1 · Ledbetter et al. · 2005 [cited by applicant]
US 20050136051A1 · Scallon · 2005 [cited by applicant]
US 20050163782A1 · Glaser et al. · 2005 [cited by applicant]
US 20050260186A1 · Bookbinder et al. · 2005 [cited by applicant]
US 20050266000A1 · Bond et al. · 2005 [cited by applicant]
US 20050266425A1 · Zauderer et al. · 2005 [cited by applicant]
US 20060008844A1 · Stemmer et al. · 2006 [cited by applicant]
US 20060025576A1 · Miller et al. · 2006 [cited by applicant]
US 20060083747A1 · Winter et al. · 2006 [cited by applicant]
US 20060104968A1 · Bookbinder et al. · 2006 [cited by applicant]
US 20060120960A1 · Deyev et al. · 2006 [cited by applicant]
US 20060141581A1 · Gillies et al. · 2006 [cited by applicant]
US 20060204493A1 · Huang et al. · 2006 [cited by applicant]
US 20060263367A1 · Fey et al. · 2006 [cited by applicant]
US 20070004909A1 · Johnson et al. · 2007 [cited by applicant]
US 20070036783A1 · Humeau et al. · 2007 [cited by applicant]
US 20070061900A1 · Murphy et al. · 2007 [cited by applicant]
US 20070087381A1 · Kojima · 2007 [cited by applicant]
US 20070105105A1 · Clelland et al. · 2007 [cited by applicant]
US 20070117126A1 · Sidhu et al. · 2007 [cited by applicant]
US 20070128150A1 · Norman · 2007 [cited by applicant]
US 20070141049A1 · Bredehorst et al. · 2007 [cited by applicant]
US 20070154901A1 · Thogersen et al. · 2007 [cited by applicant]
US 20070160598A1 · Dennis et al. · 2007 [cited by applicant]
US 20070178106A1 · Romagne · 2007 [cited by applicant]
US 20070184052A1 · Lin et al. · 2007 [cited by applicant]
US 20070231322A1 · Romagne et al. · 2007 [cited by applicant]
US 20070237764A1 · Birtalan et al. · 2007 [cited by applicant]
US 20070274985A1 · Dubel et al. · 2007 [cited by applicant]
US 20070292936A1 · Barthelemy et al. · 2007 [cited by applicant]
US 20080050370A1 · Glaser et al. · 2008 [cited by applicant]
US 20080063717A1 · Romagne et al. · 2008 [cited by applicant]
US 20080069820A1 · Fuh et al. · 2008 [cited by applicant]
US 20080152645A1 · Pardridge et al. · 2008 [cited by applicant]
US 20080171855A1 · Rossi et al. · 2008 [cited by applicant]
US 20080241884A1 · Shitara et al. · 2008 [cited by applicant]
US 20080247944A1 · Graziano et al. · 2008 [cited by applicant]
US 20080254512A1 · Capon · 2008 [cited by applicant]
US 20080260738A1 · Moore et al. · 2008 [cited by applicant]
US 20080299137A1 · Svendsen et al. · 2008 [cited by applicant]
US 20090002360A1 · Chen et al. · 2009 [cited by applicant]
US 20090010843A1 · Spee et al. · 2009 [cited by applicant]
US 20090130106A1 · Christopherson et al. · 2009 [cited by applicant]
US 20090148905A1 · Ashman et al. · 2009 [cited by applicant]
US 20090155275A1 · Wu et al. · 2009 [cited by applicant]
US 20090162359A1 · Klein et al. · 2009 [cited by applicant]
US 20090162360A1 · Klein et al. · 2009 [cited by applicant]
US 20090175851A1 · Klein et al. · 2009 [cited by applicant]
US 20090175867A1 · Thompson et al. · 2009 [cited by applicant]
US 20090214533A1 · Clynes · 2009 [cited by applicant]
US 20090232811A1 · Klein et al. · 2009 [cited by applicant]
US 20090234105A1 · Gervay-Hague et al. · 2009 [cited by applicant]
US 20090263392A1 · Igawa et al. · 2009 [cited by applicant]
US 20090274649A1 · Qu et al. · 2009 [cited by applicant]
US 20090280116A1 · Smith et al. · 2009 [cited by applicant]
US 20090324538A1 · Wong et al. · 2009 [cited by applicant]
US 20100015133A1 · Igawa et al. · 2010 [cited by applicant]
US 20100028330A1 · Collins et al. · 2010 [cited by applicant]
US 20100047169A1 · Mandelboim et al. · 2010 [cited by applicant]
US 20100168393A1 · Clube et al. · 2010 [cited by applicant]
US 20100260704A1 · Berenguer et al. · 2010 [cited by applicant]
US 20100316645A1 · Imhof-Jung et al. · 2010 [cited by applicant]
US 20110014659A1 · Balazs et al. · 2011 [cited by applicant]
US 20110054151A1 · Lazar et al. · 2011 [cited by applicant]
US 20110091372A1 · Ghayur et al. · 2011 [cited by applicant]
US 20110150892A1 · Thudium et al. · 2011 [cited by applicant]
US 20110177073A1 · Van Berkel et al. · 2011 [cited by applicant]
US 20110177093A1 · Kalled et al. · 2011 [cited by applicant]
US 20110250170A1 · Pedretti et al. · 2011 [cited by applicant]
US 20110287056A1 · Gu et al. · 2011 [cited by applicant]
US 20110293613A1 · Brinkmann et al. · 2011 [cited by applicant]
US 20120034221A1 · Bonvini et al. · 2012 [cited by applicant]
US 20120039906A1 · Olive · 2012 [cited by applicant]
US 20120114649A1 · Langermann et al. · 2012 [cited by applicant]
US 20120149876A1 · Von Kreudenstein et al. · 2012 [cited by applicant]
US 20120184716A1 · Fischer et al. · 2012 [cited by applicant]
US 20120201746A1 · Liu et al. · 2012 [cited by applicant]
US 20120213768A1 · Oh et al. · 2012 [cited by applicant]
US 20120294857A1 · Sentman et al. · 2012 [cited by applicant]
US 20130017200A1 · Scheer et al. · 2013 [cited by applicant]
US 20130022601A1 · Brinkmann et al. · 2013 [cited by applicant]
US 20130078249A1 · Ast et al. · 2013 [cited by applicant]
US 20130129723A1 · Blankenship et al. · 2013 [cited by applicant]
US 20130165638A1 · Hsu et al. · 2013 [cited by applicant]
US 20130178605A1 · Blein et al. · 2013 [cited by applicant]
US 20130195849A1 · Spreter Von Kreudenstein et al. · 2013 [cited by applicant]
US 20130243775A1 · Papadopoulos et al. · 2013 [cited by applicant]
US 20130266568A1 · Brinkmann et al. · 2013 [cited by applicant]
US 20130267686A1 · Brinkmann et al. · 2013 [cited by applicant]
US 20130273055A1 · Borges et al. · 2013 [cited by applicant]
US 20130273089A1 · Getts et al. · 2013 [cited by applicant]
US 20130280208A1 · Stepkowski et al. · 2013 [cited by applicant]
US 20130303396A1 · Igawa et al. · 2013 [cited by applicant]
US 20130317200A1 · Elson et al. · 2013 [cited by applicant]
US 20140037621A1 · Tsurushita et al. · 2014 [cited by applicant]
US 20140044728A1 · Takayanagi et al. · 2014 [cited by applicant]
US 20140051833A1 · Fischer et al. · 2014 [cited by applicant]
US 20140051835A1 · Dixit et al. · 2014 [cited by applicant]
US 20140072528A1 · Gerdes et al. · 2014 [cited by applicant]
US 20140072581A1 · Dixit et al. · 2014 [cited by applicant]
US 20140079689A1 · Elliott et al. · 2014 [cited by applicant]
US 20140079691A1 · McConnell et al. · 2014 [cited by applicant]
US 20140099254A1 · Chang et al. · 2014 [cited by applicant]
US 20140154254A1 · Kannan et al. · 2014 [cited by applicant]
US 20140199294A1 · Mimoto et al. · 2014 [cited by applicant]
US 20140200331A1 · Corper et al. · 2014 [cited by applicant]
US 20140227265A1 · Wu et al. · 2014 [cited by applicant]
US 20140242075A1 · Parren et al. · 2014 [cited by applicant]
US 20140242077A1 · Choi et al. · 2014 [cited by applicant]
US 20140256916A1 · Kruip et al. · 2014 [cited by applicant]
US 20140308285A1 · Yan et al. · 2014 [cited by applicant]
US 20140322212A1 · Brogdon et al. · 2014 [cited by applicant]
US 20140322221A1 · Miller et al. · 2014 [cited by applicant]
US 20140348839A1 · Chowdhury et al. · 2014 [cited by applicant]
US 20140363426A1 · Moore et al. · 2014 [cited by applicant]
US 20140377269A1 · Mabry et al. · 2014 [cited by applicant]
US 20150017187A1 · Thanos et al. · 2015 [cited by applicant]
US 20150018529A1 · Humphreys et al. · 2015 [cited by applicant]
US 20150056199A1 · Kumar et al. · 2015 [cited by applicant]
US 20150098900A1 · Ebens et al. · 2015 [cited by applicant]
US 20150133638A1 · Wranik et al. · 2015 [cited by applicant]
US 20150166661A1 · Chen et al. · 2015 [cited by applicant]
US 20150166670A1 · Castoldi et al. · 2015 [cited by applicant]
US 20150175707A1 · De Jong et al. · 2015 [cited by applicant]
US 20150203591A1 · Yancopoulos et al. · 2015 [cited by applicant]
US 20150211001A1 · Ohrn et al. · 2015 [cited by applicant]
US 20150218260A1 · Klein et al. · 2015 [cited by applicant]
US 20150232560A1 · Heindl et al. · 2015 [cited by applicant]
US 20150315296A1 · Schaefer et al. · 2015 [cited by applicant]
US 20150337049A1 · Labrijn et al. · 2015 [cited by applicant]
US 20150344570A1 · Igawa et al. · 2015 [cited by applicant]
US 20150353636A1 · Parren et al. · 2015 [cited by applicant]
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