Granted Patent
B2
US 12,279,630 · App. 16/961,942 · Granted Apr 22, 2025
Treatment and prevention of seed allergies
Assignees:
Tel HaShomer Medical Research Infrastructure and Services Ltd.; The State of Israel, Ministry of Agriculture & Rural Development, Agricultural Research Organization (ARO) (Volcani Center)
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Abstract
A composition of matter comprising an extract of a plurality of seeds of an edible plant of interest is disclosed. Use of the composition and methods of generating same are also disclosed.
Claims (8)
1. A method of inducing desensitization to peanut seeds in an allergic subject comprising providing a composition to the subject using a treatment regimen that induces desensitization to peanut seeds in said allergic subject, wherein the composition comprises an extract of a plurality of non-mature peanut seeds, wherein allergic proteins of said non-mature peanut seeds are amenable to heat denaturation and are denatured by heating to a temperature between 50-500° C., wherein said non-mature peanut seeds are at a developmental stage whereby the peanut seeds occupy between 40-60% of the pod volume, said composition of matter being devoid of fully mature peanut seeds.
2. The method of claim 1 , wherein said composition is provided orally.
3. The method of claim 2 , wherein said treatment regimen comprises initially providing said composition as a cooked product.
4. The method of claim 3 , wherein said treatment regimen subsequently comprises providing said composition as a raw product if the subject displays tolerance to said cooked product.
5. The method of claim 1 , wherein the subject is selected for treatment by evaluating the response to topical application of said composition.
6. The method of claim 1 , wherein said composition is provided in an amount between 0.1-2 gm of protein per week.
7. The method of claim 1 , wherein said subject is an infant.
8. The method of claim 7 , wherein said composition is a milk formula or baby food.
Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Aug 16, 2020
From: KIDON, MONA
To: TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD.
Reel/Frame 053506/0506 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Aug 16, 2020
From: HOVAV, RAN
To: THE STATE OF ISRAEL, MINISTRY OF AGRICULTURE & RURAL DEVELOPMENT, AGRICULTURAL RESEARCH ORGANIZATION (ARO) (VOLCANI CENTER)
Reel/Frame 053506/0509 →
Continuity (2)
Provisional Application
62617642
· Jan 16, 2018
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