Polymer-based macromolecular prodrugs
Provided are macromolecular prodrugs in which camptothecin analogs are covalently bonded to polymers via ester bonds that are labile under physiological conditions. Also provided are methods of treating cancer, especially neuroblastoma with the macromolecular prodrugs.
1. A macromolecular prodrug which is PEG-[SN22] 4 , having the following structure:
wherein:
n=110 in average and
PE is
2. A method of treating neuroblastoma, comprising administering an effective amount of the macromolecular prodrug of claim 1 to a subject in need thereof.
3. The method of claim 2 , wherein the subject is a human.
4. A method of treating a subject with a solid tumor, comprising administering an effective amount of the macromolecular prodrug of claim 1 to a subject in need thereof.
5. The method of claim 4 , wherein the subject is a human.
6. A method of treating a subject with a brain tumor, comprising administering an effective amount of the macromolecular prodrug of claim 1 to a subject in need thereof.
7. The method of claim 6 , wherein the subject is a human.