Method for monitoring metabolism before and after exercise or injury using salivary micro-RNAs
A method for evaluating or monitoring metabolic effects of exercise or injury by detecting and/or quantifying microR-NAs in saliva. Compositions and methods of treatment based on detection of microRNAs.
1. A method for selecting an injury recovery exercise regimen for a subject having a concussion or traumatic brain injury (TBI) comprising:
detecting pre-exercise levels of miR-7154-3p, miR-200b-5p, miR-5582-3p, miR-6859-3p, miR-6751-5p, and miR-4419a in a saliva sample obtained from the subject having the concussion or TBI,
administering an injury recovery exercise regimen to said subject,
detecting post-exercise levels of miR-7154-3p, miR-200b-5p, miR-5582-3p, miR-6859-3p, miR-6751-5p, and miR-4419a in a saliva sample obtained from the subject;
selecting the injury recovery regimen for said subject when the post-exercise levels of miR-7154-3p, miR-200b-5p, miR-5582-3p, miR-6859-3p, miR-6751-5p, and miR-4419a are increased in comparison to the pre-exercise levels of miR-7154-3p, miR-200b-5p, miR-5582-3p, miR-6859-3p, miR-6751-5p, and miR-4419a; and
continuing to administer the selected injury recovery exercise regimen to said subject.
2. The method of claim 1 , further comprising detecting pre-exercise levels of miR-3671 and/or miR-5095 in the saliva sample obtained from the subject and detecting post exercise levels of miR-3671 and/or miR-5095 in the saliva sample obtained from the subject.
3. The method of claim 1 , wherein the subject has had a concussion.
4. The method of claim 1 , wherein the subject has had a TBI.
5. The method of claim 1 , wherein the regimen comprises aerobic exercise.
6. The method of claim 1 , wherein the regimen comprises jogging or running.
7. The method of claim 1 , wherein the regimen comprises a sports training regimen.
8. The method of claim 1 , wherein the regimen further comprises a health or weight loss regimen.