IP Library › Granted Patent US 11,465,135
Granted Patent B2
US 11,465,135 · App. 16/976,151 · Granted Oct 11, 2022

Bifunctional chiral organocatalytic compound having excellent enantioselectivity, preparation method therefor, and method for producing non-natural gamma-amino acid from nitro compound by using same

Inventors: Deok-Chan Ha (Seoul, KR); Jae Ho Shim (Seoul, KR)
Assignee: Korea University Research and Business Foundation
B01J31/0237B01J31/0215B01J31/0245C07C201/12C07C227/22C07C335/12C07C335/16C07D207/28C07C205/04C07C229/36
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Quick Facts
Patent No.
US 11,465,135
App. No.
16/976,151
Granted
Oct 11, 2022
Kind
B2
Abstract

The present invention relates to a bifunctional chiral organocatalytic compound having excellent enantioselectivity, a preparation method therefor, and a method for producing a non-natural gamma amino acid from a nitro compound by using the chiral organocatalytic compound. According to the present invention, the bifunctional chiral organocatalytic compound having excellent enantioselectivity can be easily synthesized, gamma-amino acids with high optical selectivity can be obtained at a high yield by an economical and convenient method using the chiral organocatalytic compound, and various (R)-configuration gamma-amino acids, which are not present in nature, can be produced with high optical purity in large quantities by using a small amount of a catalyst, and therefore, the present invention can be widely utilized in various industrial fields including the pharmaceutical industry.

Claims (1)

1. A chiral organocatalyst selected from the group consisting of the following compounds:

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 27, 2020
From: HA, DEOK-CHAN; SHIM, JAE HO
To: KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION
Reel/Frame 053613/0405 →
Priority Claims (2)
KR 10-2018-0024695 · Feb 28, 2018 · national
KR 10-2018-0161967 · Dec 14, 2018 · national
Continuity (1)
Related Publication 20200406243A1 · Dec 31, 2020
Cited By (1)
US 12,612,574