IP Library Granted Patent US 11,312,839
Granted Patent B2
US 11,312,839 · App. 16/980,562 · Granted Apr 26, 2022

Method and composition for preserving sodium nitroprusside solutions

Inventor: Dorian Cauceglia (Cape Coral, FL)
Assignee: HF Scientific, LLC
C08K5/56C08K5/05C08K5/13C01C3/08C01C3/12C09K15/00
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Quick Facts
Patent No.
US 11,312,839
App. No.
16/980,562
Granted
Apr 26, 2022
Kind
B2
Abstract

A method to extend a shelf life of a sodium nitroprusside solution includes: dissolving about two parts by weight of a 2-hydroxybenzyl alcohol and about one part by weight of a sodium nitroprusside in about seventy-five parts by weight of a polyethylene glycol. Compositions for preserving a sodium nitroprusside solution are also described.

Claims (24)

1. A method to extend a shelf life of a sodium nitroprusside solution comprising: dissolving about two parts by weight of a 2-hydroxybenzyl alcohol and about one part by weight of a sodium nitroprusside in about seventy-five parts by weight of a polyethylene glycol.

2. The method of claim 1 , comprising: dissolving 3 g of 2-hydroxybenzyl alcohol and 1.5 g sodium nitroprusside in 100 ml of polyethylene glycol 300 at about 60° C.

3. The method of claim 1 , wherein said polyethylene glycol comprises a polyethylene glycol 300.

4. The method of claim 1 , wherein said polyethylene glycol comprises a PEG-400.

5. The method of claim 1 , wherein said polyethylene glycol comprises a PEG-1000.

6. A composition for preserving a sodium nitroprusside solution comprising: about two parts by weight of a 2-hydroxybenzyl alcohol and about one part by weight of a sodium nitroprusside dissolved in about seventy-five parts by weight of a polyethylene glycol.

7. The composition of claim 6 , comprising: 3 g of 2-hydroxybenzyl alcohol and 1.5 g sodium nitroprusside dissolved in 100 ml of polyethylene glycol 300 at about 60° C.

8. The composition of claim 6 , wherein said sodium nitroprusside solution is capable of catalyzing an indophenol monochloramine reaction.

9. A composition for preserving a sodium nitroprusside solution comprising: about two parts by weight of a 2-hydroxybenzyl alcohol and about one part by weight of a sodium nitroprusside dissolved in a component comprising a liquid selected from the group consisting of polyethylene glycol, ethane-1,2-diol, propane-1,2-diol, a polymer with a H—(O—CH2—CH2)n-OH structure either linear or cross-linked, and a glycopolymer.

10. The composition of claim 9 , wherein the liquid is propane-1,2-diol, and the component comprises up to about 70% water by volume.

11. The composition of claim 9 , wherein the component comprises approximately 30% propane-1,2-diol and approximately 70% water by volume.

12. A composition for preserving a sodium nitroprusside solution comprising: a 2-hydroxybenzyl alcohol and a sodium nitroprusside dissolved in a mixture of propane-1,2-diol and water.

13. The composition of claim 12 , wherein the mixture comprises approximately 30% propane-1,2-diol and approximately 70% water by volume.

14. The composition of claim 13 , wherein the composition comprises approximately 1% sodium nitroprusside by weight.

15. The composition of claim 14 , wherein the ratio of the 2-hydroxybenzyl alcohol to the sodium nitroprusside is about two parts by weight to one part by weight.

16. The composition of claim 12 , wherein the composition comprises approximately 1% sodium nitroprusside by weight.

17. The composition of claim 16 , wherein the ratio of the 2-hydroxybenzyl alcohol to the sodium nitroprusside is about two parts by weight to one part by weight.

18. A method to extend a shelf life of a sodium nitroprusside solution comprising:

dissolving a 2-hydroxybenzyl alcohol and a sodium nitroprusside in a mixture of propane-1,2-diol and water.

19. The method of claim 18 , wherein the mixture comprises approximately 30% propane-1,2-diol and approximately 70% water by volume.

20. The method of claim 19 , wherein the composition comprises approximately 1% sodium nitroprusside by weight.

21. The method of claim 20 , wherein the ratio of the 2-hydroxybenzyl alcohol to the sodium nitroprusside is about two parts by weight to one part by weight.

22. The method of claim 18 , wherein the composition comprises approximately 1% sodium nitroprusside by weight.

23. The method of claim 22 , wherein the ratio of the 2-hydroxybenzyl alcohol to the sodium nitroprusside is about two parts by weight to one part by weight.

Assignments (2)
CHANGE OF NAME Recorded Apr 30, 2021
From: HF SCIENTIFIC, INC.
To: HF SCIENTIFIC, LLC
Reel/Frame 056109/0278 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 31, 2020
From: CAUCEGLIA, DORIAN
To: HF SCIENTIFIC, INC.
Reel/Frame 054783/0719 →
Continuity (2)
Provisional Application 62643978 · Mar 16, 2018
Related Publication 20210002457A1 · Jan 7, 2021