IP Library Granted Patent US 12,138,244
Granted Patent B2
US 12,138,244 · App. 16/982,523 · Granted Nov 12, 2024

Drug and method of treating or preventing renal disease using drug

Inventors: Terumasa Hashimoto (Tokyo, JP); Keita Shibata (Tokyo, JP); Kazuo Honda (Tokyo, JP); Koji Nobe (Tokyo, JP)
Assignees: SHOWA UNIVERSITY; JI XING PAHRMACEUTICALS HONG KONG LIMITED
A61K31/407A61P13/12
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Quick Facts
Patent No.
US 12,138,244
App. No.
16/982,523
Granted
Nov 12, 2024
Kind
B2
Abstract

A drug for renal disease, the drug including a compound represented by the following Formula (I) as an active ingredient.

Claims (22)

1. A method of treating renal disease in a subject having renal disease, the method comprising administering the drug comprising a compound represented by the following Formula (I) or a salt thereof as an active ingredient to the subject at an effective amount for treating renal disease, wherein the renal disease is acute renal disease caused by acute renal ischemia:

wherein * represents a bonding site.

2. The method according to claim 1 , wherein the effective amount is 0.01 to 30 mg/kg as a single effective dose for an adult.

3. The method according to claim 1 , wherein the drug is administered with other medical agent simultaneously or/and at different times.

4. The method according to claim 1 , wherein the drug is administered with an anticancer agent simultaneously or/and at different times.

5. The method according to claim 1 , wherein the drug is administered with cisplatin simultaneously or/and at different times.

6. The method according to claim 1 , wherein the compound is SMTP-7 or a salt thereof.

7. The method according to claim 1 , wherein the compound is SMTP-7.

8. A method of treating renal disease in a subject having renal disease, the method comprising administering the drug comprising a compound represented by the following Formula (I) or a salt thereof as an active ingredient to the subject at an effective amount for treating renal disease, wherein the renal disease is acute renal disease caused by cisplatin nephropathy

wherein * represents a bonding site.

9. The method according to claim 8 , wherein the effective amount is 0.01 to 30 mg/kg as a single effective dose for an adult.

10. The method according to claim 8 , wherein the drug is administered with other medical agent simultaneously or/and at different times.

11. The method according to claim 8 , wherein the drug is administered with an anticancer agent simultaneously or/and at different times.

12. The method according to claim 8 , wherein the drug is administered with cisplatin simultaneously or/and at different times.

13. The method according to claim 8 , wherein the compound represented by the Formula (I) or the salt thereof is SMTP-7.

14. A method of treating renal disease in a subject having renal disease, the method comprising administering the drug comprising a compound represented by the following Formula (I) or a salt thereof as an active ingredient to the subject at an effective amount for treating renal disease, wherein the renal disease is chronic renal disease caused by cisplatin nephropathy

wherein * represents a bonding site.

15. The method according to claim 14 , wherein the effective amount is 0.01 to 30 mg/kg as a single effective dose for an adult.

16. The method according to claim 14 , wherein the drug is administered with other medical agent simultaneously or/and at different times.

17. The method according to claim 14 , wherein the drug is administered with an anticancer agent simultaneously or/and at different times.

18. The method according to claim 14 , wherein the drug is administered with cisplatin simultaneously or/and at different times.

19. The method according to claim 14 , wherein the compound represented by the Formula (I) or the salt thereof is SMTP-7.

Assignments (5)
CHANGE OF NAME Recorded Jan 8, 2026
From: SHOWA UNIVERSITY
To: SHOWA MEDICAL UNIVERSITY
Reel/Frame 074300/0981 →
CHANGE OF NAME Recorded Dec 4, 2024
From: JI XING PHARMACEUTICALS HONG KONG LIMITED
To: CORXEL PHARMACEUTICALS HONG KONG LIMITED
Reel/Frame 069492/0589 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 30, 2024
From: BIOGEN MA INC.
To: JI XING PHARMACEUTICALS HONG KONG LIMITED
Reel/Frame 066379/0891 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 20, 2021
From: TMS CO., LTD.
To: BIOGEN MA INC.
Reel/Frame 057534/0699 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 21, 2020
From: HASHIMOTO, TERUMASA; SHIBATA, KEITA; HONDA, KAZUO; NOBE, KOJI
To: SHOWA UNIVERSITY; TMS CO., LTD.
Reel/Frame 053826/0435 →
Priority Claims (1)
JP 2018-057055 · Mar 23, 2018 · national
Continuity (1)
Related Publication 20210000794A1 · Jan 7, 2021