IP Library › Granted Patent US 11,723,910
Granted Patent B1
US 11,723,910 · App. 16/986,188 · Granted Aug 15, 2023

Compositions and methods for modulating the endothelial barrier

Inventors: Jerome William Breslin (Tampa, FL); Zeinab Yehia Khalil Motawe (Tampa, FL)
Assignee: University of South Florida
A61K31/5375A61K31/15A61K31/155A61K31/341A61K31/343A61K31/4015A61K31/4045A61K31/445A61K31/485A61K31/499
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Quick Facts
Patent No.
US 11,723,910
App. No.
16/986,188
Granted
Aug 15, 2023
Kind
B1
Abstract

Disclosed are compositions and methods for modulating endothelial barrier function.

Claims (3)

1. A method of treating a lymphatic endothelial barrier disorder in a subject in need thereof, comprising: administering to the subject a therapeutically effective amount of a sigma-1 receptor agonist or a pharmaceutically acceptable salt thereof, wherein the sigma-1 receptor agonist is PRE-084.

2. The method of claim 1 , wherein the subject is a human.

3. The method of claim 1 , wherein the lymphatic endothelial barrier disorder relates to dysregulated ATP metabolism.

Assignments (2)
CONFIRMATORY LICENSE Recorded Oct 17, 2023
From: UNIVERSITY OF SOUTH FLORIDA
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 065266/0734 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 5, 2021
From: BRESLIN, JEROME WILLIAM; MOTAWE, ZEINAB YEHIA KHALIL
To: UNIVERSITY OF SOUTH FLORIDA
Reel/Frame 057090/0863 →
Continuity (1)
Provisional Application 62882721 · Aug 5, 2019