Dry powder formulations for inhalation
A respirable dry powder including acetylsalicylic acid in particles has a mass median aerodynamic diameter (MMAD) within a range of about 0.5 μm to about 10 μm. The respirable dry powder may contain a pharmaceutically acceptable excipient, such as a phospholipid, in an amount ranging from about 0.1% (w/w) to about 10% (w/w) of the particles.
1. A dry powder composition comprising dry particles that comprise acetylsalicylic acid or a pharmaceutically acceptable salt thereof,
wherein the dry particles have a mass median aerodynamic diameter (MMAD) within a range of about 0.5 μm to about 10 μm,
wherein the composition further comprises one or more phospholipids in an amount ranging from about 0.1% (w/w) to about 10% (w/w) of the composition,
wherein the acetylsalicylic acid or a pharmaceutically acceptable salt thereof is in an amount greater than 50% (w/w) of the composition, and
wherein the MMAD varies less than about 10% after the dry powder composition is stored at 30° C. at 65% relative humidity for about 4 weeks or,
wherein the MMAD varies less than about 10% after the dry powder composition is stored at 50° C. at 75% relative humidity for about 2 weeks, or
wherein the MMAD varies less than about 10% after the dry powder composition is stored at 50° C. for about 5 days.
2. The dry powder composition of claim 1 , wherein the MMAD varies less than about 8% after the dry powder composition is stored at 30° C. at 65% relative humidity for about 4 weeks.
3. The dry powder composition of claim 1 , wherein the MMAD varies less than about 6% after the dry powder composition is stored at 30° C. at 65% relative humidity for about 4 weeks.
4. The dry powder composition of claim 1 , wherein the composition comprises particles having an MMAD size distribution such that said particles exhibit a DV90 less than about 20 un, a DV50 less than about 7 μm, and a DV10 less than about 2 μm.
5. The dry powder composition of claim 1 , wherein the composition comprises particles having an MMAD size distribution such that said particles exhibit a DV90 less than about 10 μm, a DV50 less than about 4 μm, and a DV10 less than about 1 μm.
6. The dry powder composition of claim 1 , wherein the composition comprises particles having an MMAD size distribution such that said particles exhibit a DV90 less than about 6 μm, a DV50 less than about 3 μm, and a DV10 less than about 1 μm.
7. The dry powder composition of claim 1 , wherein the composition comprises particles having an MMAD size distribution such that said particles exhibit a DV50 less than about 5 μm, and a DV10 less than about 2 μm.
8. The dry powder composition of claim 1 , wherein the composition comprises particles having an MMAD size distribution such that said particles exhibit a DV50 ranging from about 2.5 μm to about 4 μm, and a DV10 ranging from about 0.8 μm to about 1.5 μm.
9. The dry powder composition of claim 4 , wherein the DV90, DV50 and/or DV10 vary less than about 10% after the dry powder composition is stored at 30° C. at 65% relative humidity for about 4 weeks.
10. The dry powder composition of claim 1 , wherein acetylsalicylic acid or a pharmaceutically acceptable salt thereof is in an amount greater than 70% (w/w) of the composition.
11. The dry powder composition of claim 1 , wherein the composition comprises particles coated with a pharmaceutically acceptable excipient.
12. The dry powder composition of claim 11 , wherein the pharmaceutically acceptable excipient is a phospholipid.
13. The dry powder composition of claim 1 , wherein the phospholipid is dipalmitoyl phosphatidylcholine (DPPC), distearoyl phosphatidylcholine (DSPC), soy lecithin or a combination thereof.
14. The dry powder composition of claim 1 , wherein the phospholipid is in an amount ranging from about 1% to about 5% w/w (w/w) of the composition.
15. The dry powder composition of claim 1 , wherein the phospholipid is DSPC in an amount of about 5% (w/w) of the composition.
16. The dry powder composition of claim 1 , wherein phospholipid is soy lecithin in an amount of about 0.1% (w/w) of the composition.
17. The dry powder composition of claim 1 , wherein the MMAD ranges from about 2.0 to about 5.0 μm or from about 3.0 to about 4.0 μm.
18. A drug delivery system effective to reduce the risk of a thromboembolic event or treat thrombosis, wherein the system comprises the dry powder composition of claim 1 , and wherein acetylsalicylic acid is present at a dose ranging from about 5 mg to about 40 mg.
19. The drug delivery system of claim 18 , further comprising clopidogrel.
20. The drug delivery system of claim 18 , further comprising an excipient.
21. The drug delivery system of claim 20 , wherein the excipient is sodium lauryl sulfate (SLS), lactose, starch, cellulose, leucine, sodium citrate, maltodextrin and/or mannitol.
22. A method of treating an ischemic event, reducing the risk of a thromboembolic event or treating thrombosis, comprising, administrating to a subject in need thereof a therapeutically effective dose of the dry powder composition of claim 1 .
23. The method of claim 22 , wherein the thromboembolic event is a myocardial infraction, a transient ischemic event, or a stroke.
24. The method of claim 22 , wherein the thromboembolic event is treated within about 5 minutes of onset of the ischemic event, or treated within about 10 minutes of onset of the ischemic event, or treated within about 15 minutes of onset of the ischemic event.