IP Library Granted Patent US 11,459,299
Granted Patent B2
US 11,459,299 · App. 16/993,553 · Granted Oct 4, 2022

Conducting reactions in leidenfrost-levitated droplets

Inventors: Robert Graham Cooks (West Lafayette, IN); Christopher Pulliam (West Lafayette, IN); Ryan M. Bain (West Lafayette, IN)
Assignee: Purdue Research Foundation
C07D213/04C07C45/72C07D209/40C07J41/0005
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Quick Facts
Patent No.
US 11,459,299
App. No.
16/993,553
Granted
Oct 4, 2022
Kind
B2
Abstract

The invention generally relates to conducting reactions in Leidenfrost-levitated droplets.

Claims (25)

1. A method for forming and collecting a reaction product, the method comprising conducting a reaction within a Leidenfrost-levitated droplet while maintaining a substantially constant volume of the Leidenfrost-levitated droplet, thereby forming a reaction product within the Leidenfrost-levitated droplet; and

collecting the reaction product in the Leidenfrost-levitated droplet without evaporating the Leidenfrost-levitated droplet.

2. The method according to claim 1 , further comprising analyzing the reaction product.

3. The method according to claim 2 , wherein analyzing is by a mass spectrometry technique.

4. The method according to claim 1 , wherein maintaining the substantially constant volume comprises introducing droplets of pure solvent or the reaction mixture to the Leidenfrost-levitated droplet.

5. The method according to claim 1 , wherein the method further comprises conducting multiple reactions in multiple separate Leidenfrost-levitated droplets.

6. The method according to claim 5 , wherein the multiple separate Leidenfrost-levitated droplets are merged with each other.

7. The method according to claim 5 , wherein the multiple reactions are the same.

8. The method according to claim 5 , wherein the multiple reactions are different.

9. The method according to claim 1 , wherein the method is conducted without the use of surfactants.

10. A method for forming and collecting a reaction product, the method comprising:

introducing a first liquid droplet onto a heated surface that is at a temperate that is at or above a Leidenfrost point of the first liquid such that the first liquid droplet levitates on the heated surface, wherein the first liquid droplet comprises reagents for a reaction;

conducting a reaction in the first liquid droplet using the reagents in order to form a reaction product;

introducing one or more subsequent liquid droplets to the first liquid droplet on the heated surface such that the one or more subsequent liquid droplets merge with the first liquid droplet; and

collecting the reaction product in the first liquid droplet without evaporating the first liquid droplet.

11. The method according to claim 10 , further comprising analyzing the reaction product.

12. The method according to claim 11 , wherein analyzing is by a mass spectrometry technique.

13. The method according to claim 10 , wherein the first liquid droplet is maintained at a substantially constant volume throughout the method.

14. The method according to claim 10 , wherein the one or more subsequent liquid droplets each comprise the reagents for the reaction.

15. The method according to claim 10 , wherein the method is conducted without the use of surfactants.

16. A method for forming and collecting a reaction product, the method comprising:

conducting a reaction within a Leidenfrost-levitated droplet, thereby forming a reaction product within the Leidenfrost-levitated droplet; and

collecting the reaction product in the Leidenfrost-levitated droplet without evaporating the Leidenfrost-levitated droplet.

17. The method according to claim 16 , wherein the droplet reduces in volume as the reaction occurs.

18. The method according to claim 16 , wherein a rate of the reaction is accelerated as compared to a rate of the reaction conducted outside of the Leidenfrost-levitated droplet.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 14, 2021
From: COOKS, ROBERT GRAHAM; PULLIAM, CHRISTOPHER; BAIN, RYAN M.
To: PURDUE RESEARCH FOUNDATION
Reel/Frame 054918/0088 →
CONFIRMATORY LICENSE Recorded Oct 23, 2020
From: PURDUE UNIVERSITY
To: UNITED STATES DEPARTMENT OF ENERGY
Reel/Frame 054193/0365 →
Continuity (4)
Continuation 15613520 · Jun 5, 2017
Provisional Application 62346594 · Jun 7, 2016
Provisional Application 62346213 · Jun 6, 2016
Related Publication 20210053921A1 · Feb 25, 2021