Method and system for determining a risk of hemodynamic compromise after cardiac intervention
A method and system for predicting a measure of hemodynamic compromise as a result of transcatheter cardiac treatment. The method includes providing a patient-specific anatomical model representing cardiac region and an implant model representing a three-dimensional representation of a cardiac implant. The method includes virtually deploying said implant model into said patient-specific anatomical model. A deformation of the patient-specific anatomical model is calculated as a result of implant model deployment A measure of hemodynamic compromise is determined from the virtually deployed implant model and the deformed patient-specific anatomical model.
1. A computer-based method for predicting a measure of hemodynamic compromise resulting from transcatheter structural heart intervention, comprising:
providing an implant model representing a three-dimensional representation of a cardiac implant;
providing a patient-specific anatomical model representing a patient-specific cardiac region including a first blood flow path and a deployment site for the cardiac implant in the first blood flow path;
virtually deploying the implant model into the patient-specific anatomical model at the deployment site;
calculating deformation of the implant model and of the patient-specific anatomical model caused by deployment of the implant model at the deployment site; and
determining a measure of hemodynamic compromise corresponding to the deformation of the implant model and of the patient-specific anatomical model.
2. The computer-based method of claim 1 , wherein the patient-specific anatomical model includes a second blood flow path that adjoins the first blood flow path, and the hemodynamic compromise is indicative of a measure of obstruction of the second blood flow path.
3. The computer-based method of claim 2 , wherein the measure of hemodynamic compromise is a obstructed cross-sectional area of the second blood flow path.
4. The computer-based method of claim 1 , wherein the hemodynamic compromise is indicative of a measure of obstruction of the first blood flow path.
5. The computer-based method of claim 1 , wherein the hemodynamic compromise is indicative of a measure of leakage in the first blood flow path around or through the implant model.
6. The computer-based method of claim 1 , further comprising providing the patient-specific anatomical model at a plurality of moments during a cardiac cycle, and the measure of hemodynamic compromise is determined at the plurality of moments.
7. The computer-based method of claim 1 , further comprising determining the measure of hemodynamic compromise after simulating remodeling of the patient-specific anatomical model caused by prolonged presence of the implant model.
8. The computer-based method of claim 1 , wherein the measure of hemodynamic compromise is indicative of a degree of incomplete deployment of the implant model.
9. The computer-based method of claim 1 , wherein the patient-specific anatomical model further comprises fluid pressure in the first blood flow path.
10. The computer-based method of claim 9 , wherein the measure of hemodynamic compromise is a pressure gradient in the first blood flow path.
11. The computer-based method of claim 1 , wherein the patient-specific anatomical model further comprises at least one valve leaflet of a native cardiac valve, and determining the measure of hemodynamic compromise is indicative of displacement of the at least one valve leaflet.
12. The computer-based method of claim 1 , further comprising virtually deploying the implant model into the patient-specific anatomical model at a plurality of different locations at or near the deployment site and determining the measure of hemodynamic compromise for each of the plurality of different locations.
13. The computer-based method of claim 1 , wherein virtually deploying the implant model further comprises:
providing a plurality of implant models having different geometrical or material properties, each of the plurality of implant model corresponding to a different cardiac implant; and
virtually deploying each of the implant models into the patient-specific anatomical model, and determining the measure of hemodynamic compromise for each of the plurality of implant models.
14. The computer-based method of claim 13 , further comprising determining a corresponding one of the plurality of implant models that causes a least prediction of risk of complications.
15. The computer-based method of claim 1 , further comprising displaying the measure of hemodynamic compromise on a display.
16. A system for determining a measure of hemodynamic compromise following transcatheter structural heart intervention, comprising:
a processor; and
a memory for storing instructions to be executed by the processor, the instructions programmed to:
receive an implant model representing a three-dimensional representation of a cardiac implant;
receive a patient-specific anatomical model representing a patient-specific cardiac region including a deployment site for the cardiac implant in a first blood flow path;
virtually deploy the implant model into the patient-specific anatomical model at the deployment site;
calculate deformation of the implant model and of the patient-specific anatomical model caused by deployment of the implant model; and
determine a measure of hemodynamic compromise corresponding to the deformation of the implant model and of the patient-specific anatomical model.
17. The system of claim 16 , wherein the instructions further are programmed to receive a patient-specific anatomical model that includes a second blood flow path that adjoins the first blood flow path, and to determine the measure of hemodynamic compromise as indicative of a measure of obstruction of the second blood flow path.
18. The system of claim 16 , wherein the instructions further are programmed to receive the patient-specific anatomical model at a plurality of moments during a cardiac cycle, and to determine the measure of hemodynamic compromise at the plurality of moments.
19. The system of claim 16 , wherein the instructions further are programmed to determine the measure of hemodynamic compromise as indicative of a degree of incomplete deployment of the implant model.
20. A non-transitory computer-readable medium storing computer implementable instructions that when executed by a programmable computer cause the computer to:
retrieve an implant model representing a three-dimensional representation of a cardiac implant;
retrieve a patient-specific anatomical model representing a patient-specific cardiac region, the patient-specific anatomical model including a deployment site for the cardiac implant in a first blood flow path;
virtually deploy the implant model into the patient-specific anatomical model at the deployment site;
calculate deformation of the implant model and of the patient-specific anatomical model caused by deployment of the implant model; and
determine a measure of hemodynamic compromise corresponding to the deformation of the implant model and of the patient-specific anatomical model.
21. The non-transitory computer-readable medium of claim 20 , wherein the instructions further are programmed to receive a patient-specific anatomical model that includes a second blood flow path that adjoins the first blood flow path, and to determine the measure of hemodynamic compromise as indicative of a measure of obstruction of the second blood flow path.
22. The non-transitory computer-readable medium of claim 20 , wherein the instructions further are programmed to receive the patient-specific anatomical model at a plurality of moments during a cardiac cycle, and to determine the measure of hemodynamic compromise at the plurality of moments.
23. The non-transitory computer-readable medium of claim 20 , wherein the instructions further are programmed to determine the measure of hemodynamic compromise as indicative of a degree of incomplete deployment of the implant model.