Anhydrous sodium thiosulfate and formulations thereof
Described herein is anhydrous sodium thiosulfate, methods for synthesizing anhydrous sodium thiosulfate, pharmaceutical compositions thereof, and methods of treating ototoxicity. Anhydrous sodium thiosulfate is synthesized from sodium sulfite, sulfur, and cetylpyridinium chloride. The anhydrous sodium thiosulfate is formulated into a pharmaceutical composition comprising a buffer and solvent. These compositions are useful for eliminating or reducing ototoxicity in pediatric patients receiving platinum based chemotherapeutics.
1. A pharmaceutical composition comprising aqueous anhydrous sodium thiosulfate, wherein the aqueous anhydrous sodium thiosulfate is at a concentration of about 0.5 M and further comprising about 0.004 M boric acid.
2. The pharmaceutical composition of claim 1 , wherein the pharmaceutical composition has a total volume of about 100 mL.
3. The pharmaceutical composition of claim 1 , wherein the pharmaceutical composition further comprises hydrochloric acid.
4. The pharmaceutical composition of claim 2 , wherein the pharmaceutical composition further comprises hydrochloric acid.
5. The pharmaceutical composition of claim 1 , wherein the pharmaceutical composition further comprises sodium hydroxide.
6. The pharmaceutical composition of claim 2 , wherein the pharmaceutical composition further comprises sodium hydroxide.
7. The pharmaceutical composition of claim 1 , wherein the pharmaceutical composition has a pH between about 5 and about 9.5.
8. The pharmaceutical composition of claim 1 , wherein the pharmaceutical composition has a pH between about 6.5 and about 8.9.
9. The pharmaceutical composition of claim 1 , wherein the pharmaceutical composition has a pH between about 8.6 and about 8.8.