Glucose exposure diagnostics and therapeutics related thereto
Glucose exposure can be indicative of a number of potential underlying health conditions. The present disclosure is directed to measuring glucose exposure, determined, for example, on an hourly basis. This glucose exposure, in at least one embodiment, represents a current glucose level over the span of given period (e.g., a portion of 24 hours). If a patient's glucose exposure exceeds a glucose threshold or limit (for a 24 hour period in some embodiments), then a variety of treatments may be administered to the patient to help lower overall glucose exposure (e.g., during the 24 hour period).
1. A method for treating glucose over exposure comprising:
receiving indications of glucose levels of a patient via a filament interacting with interstitial fluid on a particular interval;
determining an average glucose level for a particular hour by averaging one or more indications of the glucose levels of the patient received during the particular hour;
determining a current glucose exposure for the particular hour by summing the average glucose level for the particular hour with a summation of average glucose levels of the patient for hours preceding the particular hour in a 24-hour period;
determining a target glucose level for the particular hour by multiplying a glucose exposure limit per hour by a numerical expression of the particular hour; and
if the current glucose exposure for the particular hour exceeds the target glucose level for the particular hour, administering treatment to the patient to lower the patient's glucose exposure level to at or below a 24-hour glucose exposure limit before the end of the 24-hour period.
2. The method for treating glucose over exposure of claim 1 , wherein the treatment comprises insulin.
3. The method for treating glucose over exposure of claim 2 , wherein the treatment comprises one or more of the group comprising rapid-acting insulin, short-acting insulin, intermediate-acting insulin, mixed-insulin, or long-acting insulin.
4. The method for treating glucose over exposure of claim 1 , wherein the treatment comprises pioglitazone.
5. The method of treating glucose over exposure of claim 1 , wherein the treatment comprises one or more weight loss drugs.
6. The method of treating glucose over exposure of claim 1 , wherein the treatment comprises one or more drugs to treat nonalcoholic fatty liver disease or nonalcoholic steatohepatitis.
7. The method of treating glucose over exposure of claim 1 , wherein the glucose exposure limit per hour is based at least in part on historical glucose exposure data for the patient.
8. The method for treating glucose over exposure of claim 1 , wherein the particular interval is 15 minutes.
9. The method for treating glucose over exposure of claim 8 , wherein determining the average glucose level for the particular hour comprises averaging four of the indications of the glucose level of the patient received during the particular hour.
10. The method for treating glucose over exposure of claim 1 , wherein the particular interval is 1 minute.
11. The method for treating glucose over exposure of claim 10 , wherein determining the average glucose level for the particular hour comprises averaging sixty of the indications of the glucose level of the patient received during the particular hour.
12. The method of treating glucose over exposure of claim 1 , wherein the 24-hour glucose exposure limit comprises a summation of the glucose exposure limit per hour for 24 hours.
13. The method for treating glucose over exposure of claim 12 , wherein the average glucose levels of the patient for hours preceding the particular hour in the 24-hour period comprises at least one average glucose level based on historical data.
14. The method for treating glucose over exposure of claim 13 , wherein the at least one average glucose level based on historical data comprises an average of average glucose levels for an hour immediately preceding the particular hour and an hour in a different 24-hour period.
15. The method for treating glucose over exposure of claim 13 , wherein the at least one average glucose level based on historical data comprises an average of stored glucose exposure data for the particular hour for different 24-hour periods.
16. A method of diagnosing and treating glucose over exposure comprising:
receiving a current glucose exposure for a particular hour, wherein the current glucose exposure for the particular hour is determined by summing an average glucose level for the particular hour with a summation of average glucose levels of a patient for hours preceding the particular hour in a 24-hour period, wherein:
the average glucose level for the particular hour is determined by averaging one or more indications of a glucose level of the patient received during the particular hour; and
the one or more indications of the glucose level of the patient are derived from a filament interacting with interstitial fluid;
determining a target glucose level for the particular hour based on a glucose exposure limit; and
if the current glucose exposure for the particular hour exceeds the target glucose level for the particular hour, administering treatment to the patient to lower the patient's glucose exposure level to at or below the glucose exposure limit.
17. The method of diagnosing and treating glucose over exposure of claim 16 , wherein the glucose exposure limit is a 24-hour glucose exposure limit.
18. The method of diagnosing and treating glucose over exposure of claim 16 , wherein the glucose exposure limit is a glucose exposure limit for less than 24 hours.
19. The method for treating glucose over exposure of claim 16 , wherein the treatment comprises one or more of the group comprising rapid-acting insulin, short-acting insulin, intermediate-acting insulin, mixed-insulin, or long-acting insulin.
20. The method of treating glucose over exposure of claim 16 , wherein the treatment comprises one or more drugs to treat nonalcoholic fatty liver disease or nonalcoholic steatohepatitis.