IP Library › Granted Patent US 12,203,927
Granted Patent B2
US 12,203,927 · App. 17/012,139 · Granted Jan 21, 2025

Methods for immunoregulation by modulating plasminogen-apple-nematode (PAN) domain-containing proteins

Inventors: Wellington Muchero (Oak Ridge, TN); Carly M. Shanks (New York, NY); Debjani Pal (Knoxville, TN); Kuntal De (Knoxville, TN)
Assignee: UT-BATTELLE, LLC
G01N33/5041A61P15/08A61P35/00C12N9/22C12N15/11C12N15/113C12N15/8279G01N33/6818C12N2310/11C12N2310/20G01N2500/00
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Quick Facts
Patent No.
US 12,203,927
App. No.
17/012,139
Granted
Jan 21, 2025
Kind
B2
Abstract

The present disclosure based on the inventors' recognition that PAN domain containing proteins play important immune regulating functions. Disclosed herein are methods for modulating immune responses in plants and animals, improving in vitro fertilization efficiency, and inhibiting human cell division and cellular migration in cancer cells. Also disclosed herein are genetically modified plants that are resistant to pathogenic infections.

Claims (5)

1. A method for screening for a therapeutic compound targeting a PAN domain in a protein, comprising:

contacting the protein comprising the PAN domain with a candidate therapeutic compound, and assessing whether the compound binds specifically to the PAN domain;

wherein the protein is selected from the group consisting of a plant protein, an animal protein, a bacterial protein, a viral protein and a fungal protein; and

wherein the PAN domain has a consensus sequence as shown in SEQ ID NO: 23.

2. The method of claim 1 , wherein the PAN domain-containing protein is selected from the group consisting of hepatocyte growth factor (HGF), natriuretic peptide receptor 3 (NPR3), natriuretic peptide receptor 1 (NPR1), WRKY transcription factors, receptor-like kinase 5 (RLK5), receptor-like kinases 7 (RLK7), and S-locus receptor kinase (SRK) polypeptides.

Assignments (2)
CONFIRMATORY LICENSE Recorded Apr 14, 2022
From: UT-BATTELLE, LLC
To: U. S. DEPARTMENT OF ENERGY
Reel/Frame 059600/0787 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 5, 2022
From: MUCHERO, WELLINGTON; SHANKS, CARLY M.; PAL, DEBJANI; DE, KUNTAL
To: UT-BATTELLE, LLC
Reel/Frame 059497/0930 →
Continuity (2)
Provisional Application 62896605 · Sep 6, 2019
Related Publication 20210072228A1 · Mar 11, 2021
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