Side chain modified peptoids useful as structure-stabilizing coatings for biomaterials

Inventors: Shih-Ting Wang (Mastic, NY); Oleg Gang (Setauket, NY); Ronald N. Zuckermann (El Cerrito, CA); Carolyn R. Bertozzi (Menlo Park, CA)

Assignees: Brookhaven Science Associates LLC; The Board of Trustees of the Leland Stanford Junior University; The Regents of the University of California; The Trustees of Columbia University in the City of New York

C07K17/06 A61K47/6923 C07K1/10 C07K7/06 B82Y5/00

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Quick Facts

Patent No.: US 11,739,162
App. No.: 17/015,532
Granted: Aug 29, 2023
Kind: B2

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Abstract

The current invention pertains compositions and methods to generate compositions providing stability to biomolecules, including providing physiologically stable and functional DNA origami-based drug/gene delivery carriers by surface coating with the oligo-ethylene glycol conjugated peptoids of Formulas (I), (II), and (III).

Claims (2)

1. A composition for stabilizing a biomaterial, said composition comprising a compound of Formula (I), wherein Formula (I) comprises:

2. A stabilized nanoparticle, wherein the nanoparticle comprises a compound of Formula (I) as described in claim 1 .

Assignments (7)

CONFIRMATORY LICENSE Recorded Apr 26, 2023

From: COLUMBIA UNIV NEW YORK MORNINGSIDE

To: UNITED STATES DEPARTMENT OF ENERGY

Reel/Frame 063449/0869 →

CONFIRMATORY LICENSE Recorded May 27, 2022

From: COLUMBIA UNIV NEW YORK MORNINGSIDE

To: UNITED STATES DEPARTMENT OF ENERGY

Reel/Frame 060205/0648 →