Compositions and methods of treating neuronal injury
The present invention features methods and composition directed to treating neuronal injury, CNS lesion, and/or promoting axon regeneration using a phosphine sulfide-stabilized phosphine.
1. A method of treating a subject having a neuronal injury, the method comprising administering to the subject a composition comprising a phosphine sulfide-stabilized phosphine and a pharmaceutically acceptable carrier excipient, wherein the
phosphine sulfide-stabilized phosphine is PSP-1 having the structure
PSP-2 having the structure
phenPS having the structure
or naphPS having the structure
2. The method of claim 1 , wherein the phosphine sulfide-stabilized phosphine is PSP-2.
3. The method of claim 1 , wherein the composition comprises an amount of a phosphine sulfide-stabilized phosphine sufficient to increase axon outgrowth subsequent to nerve injury relative to the amount of axon outgrowth detected in a corresponding control cell.