SPORE-BASED PROBIOTIC SUPPLEMENTATION IN DOGS AND CONTROL OF ENDOTOXEMIA
The present invention is directed to methods of administering a probiotic composition including Bacillus subtilis, Bacillus licheniformis , and Pediococcus acidilactici to dogs to decrease endotoxemia and improve the digestive process, and related methods.
1 . A method of decreasing endotoxemia in a dog comprising the steps of:
a. providing a probiotic composition comprising Bacillus subtilis, Bacillus licheniformis , and Pediococcus acidilactici , and
b. administering the probiotic composition to the dog in an amount effective to decrease endotoxemia in the dog.
2 . The method of claim 1 , wherein said Bacillus subtilis is Bacillus subtilis HU58 and/or said Bacillus licheniformis is Bacillus licheniformis SL-307.
3 . The method of claim 1 , wherein said Bacillus subtilis, Bacillus licheniformis , and Pediococcus acidilactici total about 1 billion to about 10 billion CFU.
4 . The method of claim 3 , wherein said CFU total is about 2.5 billion to about 5 billion CFU.
5 . The method of claim 3 , wherein said CFU total is about 2 billion CFUs Bacillus subtilis HU58, about 500 million to 1 billion CFUs Pediococcus acidilactici , and about 100 million CFUs of Bacillus licheniformis.
6 . The method of claim 1 , wherein said probiotic composition is orally administered to the dog.
7 . The method of claim 4 , wherein said oral administration is for at least 30 days.
8 . The method of claim 1 , wherein said dog is a healthy dog.
9 . The method of claim 1 , wherein said dog has a disorder of the gastrointestinal tract.
10 . A method of improving digestion in the gastrointestinal tract of a dog comprising the steps of:
a. providing a probiotic composition comprising Bacillus subtilis, Bacillus licheniformis , and Pediococcus acidilactici , and
b. administering the probiotic composition to the dog in an amount effective to improve the digestive process in gastrointestinal tract of the dog.
11 . The method of claim 10 , wherein said Bacillus subtilis is Bacillus subtilis HU58 and/or said Bacillus licheniformis is Bacillus licheniformis SL-307.
12 . The method of claim 10 , wherein said Bacillus subtilis, Bacillus licheniformis , and Pediococcus acidilactici total about 1 billion to about 10 billion CFU.
13 . The method of claim 12 , wherein said CFU total is about 2.5 billion to about 5 billion CFU.
14 . The method of claim 12 , wherein said CFU total is about 2 billion CFUs Bacillus subtilis HU58, about 500 million to 1 billion CFUs Pediococcus acidilactici , and about 100 million CFUs of Bacillus licheniformis.
15 . The method of claim 12 , wherein said probiotic composition is orally administered to the dog.
16 . The method of claim 15 , wherein said oral administration is for at least 30 days.
17 . The method of claim 1 , wherein said dog is a healthy dog.
18 . The method of claim 1 , wherein said dog has a disorder of the gastrointestinal tract.
19 . A method of treating a digestive disorder in a dog comprising the steps of:
a. providing a probiotic composition comprising Bacillus subtilis, Bacillus licheniformis , and Pediococcus acidilactici , and
b. administering the probiotic composition to the dog in an amount effective to decrease or eliminate a digestive disorder symptom in the dog.
20 . The method of claim 19 , wherein said Bacillus subtilis is Bacillus subtilis HU58 and/or said Bacillus licheniformis is Bacillus licheniformis SL-307.
21 . The method of claim 19 , wherein said Bacillus subtilis, Bacillus licheniformis , and Pediococcus acidilactici total about 1 billion to about 10 billion CFU.
22 . The method of claim 21 , wherein said CFU total is about 2.5 billion to about 5 billion CFU.
23 . The method of claim 21 , wherein said CFU total is about 2 billion CFUs Bacillus subtilis HU58, about 500 million to 1 billion CFUs Pediococcus acidilactici , and about 100 million CFUs of Bacillus licheniformis.
24 . The method of claim 19 , wherein said probiotic composition is orally administered to the dog.
25 . The method of claim 22 , wherein said oral administration is for at least 30 days.