Granted Patent B2

US 12,390,112 · App. 17/023,108 · Granted Aug 19, 2025

Inventors: Karlheinz Peter (Hawthorne, AU); Nay Min Htun (South Yara, AU); Yung-Chih Chen (Box Hill South, AU)

Assignee: BAKER HEART AND DIABETES INSTITUTE

A61B5/0086A61B5/0071A61B5/0084A61B5/02007A61B5/7246A61B5/725A61B5/7275A61B5/7282A61B2576/02

Abstract

Claims (148)

1. An apparatus for detecting atherosclerotic plaques, the apparatus comprising:

a) a radiation source for generating radiation to thereby expose at least part of an artery to radiation at a first infrared wavelength, wherein the first infrared wavelength is in a range from 600 nm to 900 nm;

b) a sensor configured to sense radiation emitted from at least part of the artery at a second infrared wavelength;

c) an electronic processor configured to:

i) determine a level of autofluorescence sensed by the sensor at the second infrared wavelength in response to exposure of at least part of the artery to radiation at the first infrared wavelength; and

ii) determine a fluorescence indicator using the level of autofluorescence, the fluorescence indicator being indicative of a presence, absence, degree or vulnerability of an atherosclerotic plaque.

2. The apparatus according to claim 1 , wherein:

a) the radiation source comprises a laser;

b) the sensor comprises an infrared photodetector; and/or

c) the apparatus comprises optics for focusing radiation.

3. The apparatus according to claim 1 , wherein the apparatus comprises a catheter comprising one or more optical fibers extending between proximal and distal ends, the distal end being for insertion into the artery, and the radiation source and sensor being coupled to the proximal end.

4. The apparatus according to claim 1 , wherein the apparatus comprises a bandpass filter.

5. The apparatus according to claim 1 , wherein the first infrared wavelength is selected from the group consisting of:

a) 650 nm±50 nm;

b) 700 nm±50 nm;

c) 750 nm±50 nm;

d) 800 nm±50 nm;

e) 850 nm±50 nm;

f) 650 nm−850 nm;

g) 700 nm−850 nm;

h) 750 nm−850 nm;

i) 800 nm−850 nm;

j) 650 nm−800 nm;

k) 700 nm−800 nm;

l) 750 nm−800 nm;

m) 650 nm−700 nm;

n) 650 nm−750 nm;

o) 650 nm−800 nm;

p) 700 nm−750 nm;

q) 685 nm; and

r) 785 nm.

6. The apparatus according to claim 1 , wherein the second infrared wavelength is selected from the group consisting of:

a) different to the first infrared wavelength; and

b) longer than the first infrared wavelength.

7. The apparatus according to claim 1 , wherein the second infrared wavelength is selected from the group consisting of:

a) 700 nm±50 nm;

b) 750 nm±50 nm;

c) 800 nm±50 nm;

d) 850 nm±50 nm;

e) 900 nm±50 nm;

f) 950 nm±50 nm;

g) 1000 nm±50 nm;

h) 1050 nm±50 nm;

i) 1100 nm±50 nm;

j) 700 nm−1150 nm;

k) 750 nm−1150 nm;

l) 800 nm−1150 nm;

m) 850 nm−1150 nm;

n) 900 nm−1150 nm;

o) 950 nm−1150 nm;

p) 1000 nm−1150 nm;

q) 1050 nm−1150 nm;

r) 1100 nm−1150 nm;

s) 700 nm−1100 nm;

t) 750 nm−1100 nm;

u) 800 nm−1100 nm;

v) 850 nm−1100 nm;

w) 900 nm−1100 nm;

x) 950 nm−1100 nm;

y) 1000 nm−1100 nm;

z) 1050 nm−1100 nm;

aa) 700 nm−1050 nm;

bb) 750 nm−150 nm;

cc) 800 nm−1050 nm;

dd) 850 nm−150 nm;

ee) 900 nm−150 nm;

ff) 950 nm−150 nm;

gg) 1000 nm−150 nm;

hh) 700 nm−1000 nm;

ii) 750 nm−1000 nm;

jj) 800 nm−1000 nm;

kk) 850 nm−1000 nm;

11 ) 900 nm−1000 nm;

mm) 950 nm−1000 nm;

nn) 700 nm−950 nm;

oo) 750 nm−950 nm;

pp) 800 nm−950 nm;

qq) 850 nm−950 nm;

rr) 900 nm−950 nm;

ss) 700 nm−900 nm;

tt) 750 nm−900 nm;

uu) 800 nm−900 nm;

vv) 850 nm−900 nm;

ww) 700 nm−850 nm;

xx) 750 nm−850 nm;

yy) 800 nm−850 nm;

zz) 700 nm−800 nm;

aaa) 750 nm−800 nm;

bbb) 700 nm−750 nm;

ccc) between 650 nm and 1144 nm;

ddd) between 800 nm and 820 nm;

eee) 700 nm; and

fff) 800 nm.

8. The apparatus according to claim 1 , wherein the electronic processor is configured to:

a) compare the level of autofluorescence to a threshold; and

b) determine the fluorescence indicator using the results of the comparison.

9. The apparatus according to claim 1 , wherein the electronic processor is configured to:

a) determine an at risk level of autofluorescence sensed by the sensor at the second infrared wavelength in response to exposure of an at risk part of the artery to radiation at the first infrared wavelength, the at risk part being an area at risk of having an unstable plaque;

b) determine a healthy level of autofluorescence sensed by the sensor at the second infrared wavelength in response to exposure of a healthy part of the artery to radiation at the first infrared wavelength; and

c) determine the fluorescence indicator using the at risk level and the healthy level.

10. The apparatus according to claim 9 , wherein the electronic processor is configured to:

a) compare the at risk level to the healthy level; and

b) determine the fluorescence indicator using the results of the comparison.

11. The apparatus according to claim 9 , comprising determining if the at risk level of autofluorescence is greater than the healthy level of autofluorescence by a threshold factor of:

a) at least 2;

b) 3 or more;

c) 5 or more;

d) 10 or more; and/or

e) 15 or more.

12. The apparatus according to claim 1 , wherein the level of autofluorescence is based on an intensity of radiation emitted by the at least one part.

13. The apparatus according to claim 1 , wherein the apparatus is for detecting the vulnerability of atherosclerotic plaque, and wherein the fluorescence indicator is indicative of the vulnerability of an atherosclerotic plaque.

14. The apparatus according to claim 1 , wherein the apparatus is configured to provide representation comprising:

a) a numerical value indicative of the fluorescence indicator;

b) a symbolic value indicative of the fluorescence indicator;

c) a graphical indicator indicative of the fluorescence indicator; and/or

d) an indicator of at least one threshold.

15. The apparatus according to claim 1 , wherein the electronic processor is configured to:

a) determine a detected marker associated with a pathological condition by introducing an agent that detects the marker into the at least part of the artery; and

b) determine the fluorescence indicator at least partially using the at least one detected marker.

16. An apparatus for detecting a vulnerability of atherosclerotic plaques, the apparatus comprising:

a) a radiation source for generating radiation to thereby expose at least part of an artery to radiation at a first infrared wavelength, wherein the first infrared wavelength is in a range from 600 nm to 900 nm;

b) a sensor for sensing radiation emitted from at least part of the artery at a second infrared wavelength;

c) an electronic processor coupled to the sensor configured to:

i) determine a level of autofluorescence sensed by the sensor; and

ii) determine a fluorescence indicator using the level of autofluorescence, the fluorescence indicator being indicative of the vulnerability of an atherosclerotic plaque.

17. The apparatus according to claim 16 , wherein the apparatus comprises a catheter comprising one or more optical fibers extending between proximal and distal ends, the distal end being for insertion into the artery, and the radiation source and sensor being coupled to the proximal end.

18. The apparatus according to claim 1 , wherein the fluorescence indicator is indicative of one or more of:

a) intraplaque hemorrhage;

b) intraluminal thrombosis;

c) neovascularization;

d) one or more characteristics of plaque instability/rupture;

e) a high risk of plaque rupture;

f) a rupture prone plaque;

g) a presence of heme-degradation products;

h) a presence of heme;

i) a presence of metheme; or

j) a presence of protoporphyrin IX.

19. The apparatus according to claim 1 , wherein the apparatus is configured to:

a) determine levels of autofluorescence sensed by the sensor at one or more second infrared wavelengths in response to exposure of at least part of the artery to radiation at a plurality of first infrared wavelengths; and,

b) determine a fluorescence indicator using the levels of autofluorescence.

20. A method for detecting atherosclerotic plaques, the method comprising:

a) providing

i) a radiation source for generating radiation to thereby expose at least part of an artery to radiation at a first infrared wavelength, wherein the first infrared wavelength is in a range from 600 nm to 900 nm,

ii) a sensor for sensing radiation emitted from at least part of the artery at a second infrared wavelength, and

iii) an electronic processor

b) exposing at least part of the artery to radiation at the first infrared wavelength with the radiation source;

c) determining, with the electronic processor, a level of autofluorescence sensed by the sensor at the second infrared wavelength in response to exposure of at least part of the artery to radiation at the first infrared wavelength; and

d) determining, with the electronic processor, a fluorescence indicator using the level of autofluorescence, the fluorescence indicator being indicative of a presence, absence, degree or vulnerability of atherosclerotic plaques.

Assignments (1)

Priority Claims (1)

Continuity (2)

References Cited (139)