Isoflavonoid compounds and methods for the treatment of cancer
Provided herein is a pharmaceutical composition comprising at least one isoflavonoid. Also provided herein are methods of treating cancer, sensitizing cancer cells, and inducing apoptosis in cancer cells by administering such compositions.
1. A compound that is d-cis-3-(4-hydroxyphenyl)-4-(4-hydroxyphenyl)-8-methylchroman-7-ol provided in at least 90% enantiomeric excess, or a pharmaceutically acceptable salt thereof.
2. A kit comprising a compound that is d-cis-3-(4-hydroxyphenyl)-4-(4-hydroxyphenyl)-8-methylchroman-7-ol provided in at least 90% enantiomeric excess, or a pharmaceutically acceptable salt thereof; and a sealable, plastic infusion bag.
3. A method of treating cancer in an individual in need of cancer therapy, the method comprising administering to the individual a compound that is d-cis-3-(4-hydroxyphenyl)-4-(4-hydroxyphenyl)-8-methylchroman-7-ol provided in at least 90% enantiomeric excess, or a pharmaceutically acceptable salt thereof.
4. The method of claim 3 , wherein the compound increases or induces sensitivity of the cancer to a chemotherapeutic agent, anti-cancer agent, or radiation therapy.
5. The method of claim 3 , wherein the cancer has lost sensitivity to a chemotherapeutic agent, anti-cancer agent, or radiation therapy.
6. The method of claim 3 , wherein the cancer is bladder cancer, breast cancer, colon cancer, recital cancer, endometrial cancer, kidney cancer, leukemia, lung cancer, melanoma, non-Hodgkin lymphoma, ovarian cancer, pancreatic cancer, prostate cancer, thyroid cancer, or cancers of the brain.
7. The method of claim 3 , wherein the cancer is human breast cancer or ovarian cancer.
8. The method of claim 3 , wherein the method further comprises administering an additional anti-cancer agent selected from the group consisting of cisplatin, carboplatin, paclitaxel, gemcitabine, doxorubicin, epirubicin, cyclophosphamide, capecitabine, 5-fluorouracil, vinorelbine, trastuzumab, and bevacizumab.