IP Library Granted Patent US 11,154,526
Granted Patent B2
US 11,154,526 · App. 17/027,069 · Granted Oct 26, 2021

Methods of treating mixed dyslipidemia

Inventors: Ian Osterloh (Kent, GB); Pierre Wicker (Mystic, CT); Rene Braeckman (Richboro, PA); Paresh Soni (Mystic, CT); Mehar Manku (Birmingham, GB)
Assignee: Amarin Pharmaceuticals Ireland Limited
A61K31/202A61K9/48A61K31/222A61K31/232A61K31/40A61K31/505A61K45/06A61K47/22A61K47/26A61K47/34A61K31/74A61P3/06
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Quick Facts
Patent No.
US 11,154,526
App. No.
17/027,069
Granted
Oct 26, 2021
Kind
B2
Abstract

The present disclosure relates to, inter alia, methods of treating mixed dyslipidemia with ethyl eicosapentaenoate.

Claims (6)

1. A method of reducing triglyceride levels in a subject on anticoagulant/antiplatelet/thrombolytic therapy, having triglyceride levels of at least about 500 mg/dl, and having atrial fibrillation and/or atrial flutter, the method comprising administering to the subject about 4 g of ethyl icosapentate per day.

2. The method of claim 1 , wherein the subject is on statin therapy.

3. The method of claim 1 , wherein the subject has a baseline LDL-C level of about 40 mg/dL to about 100 mg/dL.

4. The method of claim 1 , wherein the ethyl icosapentate is present in a pharmaceutical composition and the ethyl icosapentate comprises at least about 96 wt. % of all omega-3 fatty acids in the pharmaceutical composition.

5. The method of claim 4 , wherein about 1 g of the pharmaceutical composition is present in each of 4 capsules.

6. The method of claim 1 , wherein the subject is administered the ethyl icosapentate for a period of at least about 2 years.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 21, 2020
From: OSTERLOH, IAN; WICKER, PIERRE; BRAECKMAN, RENE; SONI, PARESH; MANKU, MEHAR
To: AMARIN PHARMACEUTICALS IRELAND LIMITED
Reel/Frame 053834/0381 →
Continuity (11)
Continuation 16709492 · Dec 10, 2019
Continuation 16179763 · Nov 2, 2018
Continuation 15273430 · Sep 22, 2016
Continuation 14704329 · May 5, 2015
Continuation 14175602 · Feb 7, 2014
Continuation 13898447 · May 20, 2013
Continuation 13540319 · Jul 2, 2012
Continuation 13417899 · Mar 12, 2012
Continuation 13266085
Provisional Application 61173759 · Apr 29, 2009
Related Publication 20210000779A1 · Jan 7, 2021
Cited By (2)
US 12,246,003 US 12,427,134