Anti-viral paints and coatings and articles comprising same
Disclosed herein are material composition formulated for mitigating activity of a virus on a surface of an article. Methods of preparing such a material composition are also disclosed.
1. A method for mitigating contamination of a surface by particles of a coronavirus for which an enveloped bacterial virus characterized by having a lipid-rich viral membrane envelope is a biological surrogate, comprising:
providing a polymeric coating composition that is applied to a substrate for forming a coating of the polymeric coating composition thereon, wherein a surface of the coating supports presence of a baseline amount of infective particles of the biological surrogate brought into contact therewith;
admixing an effective specified amount of an anti-viral additive with a specified amount of the polymeric coating composition to provide an anti-viral coating composition, wherein the anti-viral additive comprises an antimicrobial peptide that disrupts microbial membranes and an enzyme that breaks ester linkages of lipids; and
applying the anti-viral coating composition on a substrate to create an anti-viral functionalized surface thereof, wherein the antimicrobial peptide and the enzyme are each included in the anti-viral additive composition in a respective amount for causing the anti-viral functionalized surface to provide an additive-induced amount of infective particles of the biological surrogate brought into contact therewith that is at least 70% less than the baseline amount of infective particles of the biological surrogate, wherein the antimicrobial peptide comprises SEQ ID NO. 40.
2. The method of claim 1 wherein the infective particles of the biological surrogate are infective PHI-6 bacteriophage particles.
3. The method of claim 2 wherein the antimicrobial peptide is SEQ ID NO. 40.
4. The method of claim 3 wherein the enzyme is lipase.
5. The method of claim 4 wherein the additive-induced amount of infective particles of the biological surrogate brought into contact with the anti-viral functionalized surface is at least 80% less than the baseline amount of infective particles of the biological surrogate.
6. The method of claim 5 wherein:
the antimicrobial peptide is present within the polymeric coating composition at a concentration of about 3% total solids; and
the enzyme is present within the polymeric coating composition at a concentration of about 1.5% total solids.
7. The method of claim 1 wherein:
the antimicrobial peptide is SEQ ID NO. 40; and
the enzyme is lipase.
8. The method of claim 1 wherein:
the antimicrobial peptide is present within the polymeric coating composition at a concentration of about 3% total solids; and
the enzyme is present within the polymeric coating composition at a concentration of about 1.5% total solids.
9. The method of claim 8 wherein:
the antimicrobial peptide is SEQ ID NO. 40;
the enzyme is lipase; and
the infective particles of the biological surrogate are infective PHI-6 bacteriophage particles.
10. The method of claim 1 wherein:
the additive-induced amount of infective particles of the biological surrogate brought into contact with the anti-viral functionalized surface is at least 80% less than the baseline amount of infective particles of the biological surrogate; and
the infective particles of the biological surrogate are infective PHI-6 bacteriophage particles.
11. The method of claim 10 wherein:
the antimicrobial peptide is present within the polymeric coating composition at a concentration of about 3% total solids; and
the enzyme is present within the polymeric coating composition at a concentration of about 1.5% total solids.