PREPARATION AND USE OF (+)-1-(3,4-DICHLOROPHENYL)-3-AZABICYCLO[3.1.0]HEXANE IN THE TREATMENT OF CONDITIONS AFFECTED BY MONOAMINE NEUROTRANSMITTERS
The present invention relates to (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane and pharmaceutically acceptable active salts, polymorphs, glycosylated derivatives, metabolites, solvates, hydrates, and/or prodrugs of (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane and their use alone or in combination with additional psychotherapeutic compositions in the treatment of conditions affected by monoamine neurotransmitters, including treatment of refractory individuals.
1 . A method for treating depression in a human comprising administering to a human in need of treatment for depression a pharmaceutical composition comprising an effective amount of a (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane agent comprising (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane or a pharmaceutically acceptable active salt, polymorph, glycosylated derivative, metabolite, solvate, hydrate, or prodrug thereof, wherein the (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane or a pharmaceutically acceptable active salt, polymorph, glycosylated derivative, metabolite, solvate, hydrate, or prodrug thereof is substantially free of the corresponding (−) enantiomer.
2 . The method of claim 1 , wherein the pharmaceutical composition further comprises an additional psychotherapeutic agent, wherein the additional psychotherapeutic agent is an antidepressant, anti-psychotic, anti-convulsant or anxiolytic agent.
3 . The method of claim 2 , wherein the additional psychotherapeutic agent is a tri-cyclic antidepressant, specific monoamine reuptake inhibitor, selective serotonin reuptake inhibitor, selective norepinephrine or noradrenaline reuptake inhibitor, selective dopamine reuptake inhibitor, multiple monoamine reuptake inhibitor, monoamine oxidase inhibitor, atypical antidepressant, atypical antipsychotic, anticonvulsant, or opiate agonist.
4 . The method of claim 1 , wherein the (±)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane or a pharmaceutically acceptable active salt, polymorph, glycosylated derivative, metabolite, solvate, hydrate, or prodrug thereof has no more than 2% w/w of the corresponding (−) enantiomer.
5 . The method of claim 1 , wherein the (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane or a pharmaceutically acceptable active salt, polymorph, glycosylated derivative, metabolite, solvate, hydrate, or prodrug thereof has no more than 1% w/w of the corresponding (−) enantiomer.
6 . The method of claim 1 , wherein the (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane agent is Polymorph A of an acid addition salt of (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane in crystalline form substantially free of other geometric, optical and polymorphic isomers thereof
7 . The method of claim 6 , wherein the acid addition salt is a hydrochloride salt.
8 . The method of claim 1 , wherein the (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane agent is Polymorph 13 of an acid addition salt of (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane in crystalline form substantially free of other geometric, optical and polymorphic isomers thereof.
9 . The method of claim 8 , wherein the acid addition salt is a hydrochloride salt.
10 . The method of claim 1 , wherein the (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane agent is Polymorph C of an acid addition salt of (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane in crystalline form substantially free of other geometric, optical and polymorphic isomers thereof.
11 . The method of claim 10 , wherein the acid addition salt is a hydrochloride salt.
12 . The method of claim 1 , wherein the (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane agent is a solvate.
13 . The method of claim 1 , wherein the (4)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane agent is present in said oral unit dosage form in the amount of about 10 mg to about 300 mg.
14 . The method of claim 1 , wherein the effective amount is effective to decrease depressive symptoms.
15 . The method of claim 14 , wherein the effective amount is effective to decrease the human's score on a Montgomery Asberg Depression Rating Scale to less than or equal to 12.
16 . The method of claim 14 , wherein the effective amount is effective to decrease the human's score on a Hamilton Rating Scale for Depression to less than or equal to 7.
17 . The method of claim 14 , wherein the effective amount is effective to decrease the human's score on a Clinical Global Impression-Improvement score to less than or equal to 2.
18 . The method of claim 1 , wherein the human in need of treatment for depression has been unresponsive to a previous course of other antidepressants.
19 . The method of claim 18 , wherein the other antidepressant is a selective serotonin reuptake inhibitor.
20 . The method of claim 19 , wherein the selective serotonin reuptake inhibitor is citalopram.
21 . A method for increasing monoamine neurotransmitter levels or selectively inhibiting biogenic amine reuptake comprising administering to an individual in need of increased levels of monoamine neurotransmitters an effective amount of a (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane agent comprising (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane or a pharmaceutically acceptable active salt, polymorph, glycosylated derivative, metabolite, solvate, hydrate, or prodrug thereof, wherein the (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane or a pharmaceutically acceptable active salt, polymorph, glycosylated derivative, metabolite, solvate, hydrate, or prodrug thereof is substantially free of the corresponding (−) enantiomer.
22 - 64 . (canceled)
65 . The method of claim 1 , wherein the pharmaceutical composition comprises a sustained dosage release form of the effective amount of (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane agent comprising (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane or a pharmaceutically acceptable active salt, polymorph, glycosylated derivative, metabolite, solvate, hydrate, or prodrug thereof, wherein the (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane or a pharmaceutically acceptable active salt, polymorph, glycosylated derivative, metabolite, solvate, hydrate, or prodrug thereof is substantially free of the corresponding (−) enantiomer.
66 - 72 . (canceled)
73 . The method of claim 1 , wherein the pharmaceutical composition comprises a unit oral dosage form comprising from about 25 to 200 mg. of (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane or a pharmaceutically acceptable salt thereof, a pharmaceutically acceptable carrier in an amount of from about 30% to 50% of weight of said composition, and from about 15% to 45% by weight, of said composition of, a hydroxypropyl methyl cellulose hydrophilic slow release polymer matrix, said unit dosage being orally administered to said patient from once to twice a day.
74 - 79 . (canceled)
80 . A unit oral dosage form comprising a composition containing an active ingredient of from about 25 to 200 mg. of (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane or a pharmaceutically acceptable salt thereof, from about 30% to 50% of weight of said composition of pharmaceutically acceptable carrier and from about 15% to about 45% of weight of said composition of a hydroxypropyl methyl cellulose hydrophilic slow release polymer matrix.
81 - 92 . (canceled)