IP Library Granted Patent US 12,194,103
Granted Patent B2
US 12,194,103 · App. 17/040,455 · Granted Jan 14, 2025

Immunosuppressive materials and related methods

Inventors: Shaoyi Jiang (Seattle, WA); Bowen Li (Seattle, WA); Priyesh Jain (Seattle, WA)
Assignee: University of Washington
A61K47/585A61K38/44A61K47/6903C07F9/091C08F299/00C12Y107/03003
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Quick Facts
Patent No.
US 12,194,103
App. No.
17/040,455
Granted
Jan 14, 2025
Kind
B2
Abstract

Zwitterionic phosphatidylserine (ZPS) monomers, ZPS polymers and ZPS copolymers, methods for making the ZPS monomers, ZPS polymers, and ZPS copolymers, compositions and materials that include ZPS polymers and ZPS copolymers, and methods for using the ZPS monomers, ZPS polymers, and ZPS copolymers.

Claims (62)

1. A particle having micro- or nanoscale dimensions, comprising one or more zwitterionic phosphatidylserine polymers coupled to the particle, wherein the one or more zwitterionic phosphatidylserine polymers have repeating units having the formula:

wherein

* indicates the point of attachment of the repeating unit to other repeating units in the polymer or copolymer, or polymer or copolymer terminal groups;

B is a polymer backbone;

L 2 is a linker group selected from —(CH 2 ) x —, —C(═O)NH(CH 2 ) x —, —C(═O)O(CH 2 ) x —, —C(═O)OC(═O)O(CH 2 ) x —, —(CH 2 ) x —O—(CH 2 ) x —, and —(CH 2 ) x —S—S—(CH 2 ) x —, where x at each occurrence is an integer independently selected from 1 to 20;

R 2 and R 3 are independently selected from the group consisting of hydrogen, C 1 -C 20 alkyl, and C 6 -C 12 aryl;

m is an integer from 1 to 20;

p is an integer from 1 to 20; and

n is an integer from about 10 to about 500.

2. The particle of claim 1 , wherein the particle is a biomolecule.

3. The particle of claim 2 , wherein the biomolecule is a protein, a nucleic acid, a glycoprotein, a lipid, or a proteoglycan.

4. The particle of claim 2 , wherein the biomolecule is a protein selected from an enzyme, a signaling protein, a haemostasis or a thrombosis protein, a vaccine, a complement system protein, or an antibody or a functional fragment or characteristic portion thereof.

5. The particle of claim 2 , wherein the biomolecule is a small molecule therapeutic agent.

6. The particle of claim 1 , wherein the particle is a drug delivery vehicle.

7. The particle of claim 1 , wherein the particle is a cell, a virus, or a bacterium.

8. The particle of claim 1 , wherein the particle is a hydrogel.

9. The particle of claim 1 , wherein the particle is a metal, a metal oxide, a ceramic, a synthetic polymer, a natural polymer, a crystal, a semiconductor material, a grapheme, a graphene oxide, an iron oxide, or a silica, or a quantum dot.

10. The particle of claim 1 , wherein the one or more zwitterionic phosphatidylserine polymers have repeating units having the formula:

wherein

* indicates the point of attachment of the repeating unit to other repeating units in the polymer or copolymer, or polymer or copolymer terminal groups;

R 1 is selected from the group consisting of hydrogen, fluorine, trifluoromethyl, cyano, C 1 -C 20 alkyl, and C 6 -C 12 aryl;

R 2 , and R 3 are independently selected from hydrogen and C 1 -C 6 alkyl;

X is O or NH,

n is an integer from 1 to 20;

m is an integer from 1 to 20;

p is an integer from 1 to 20; and

a is an integer from about 10 to about 500.

11. A surface of a substrate having one or more zwitterionic phosphatidylserine polymers covalently coupled thereto, wherein the one or more zwitterionic phosphatidylserine polymers have repeating units having the formula:

wherein

* indicates the point of attachment of the repeating unit to other repeating units in the polymer or copolymer, or polymer or copolymer terminal groups;

B is a polymer backbone;

L 2 is a linker group selected from —(CH 2 ) x —, —C(═O)NH(CH 2 ) x —, —C(═O)O(CH 2 ) x —, —C(═O)OC(═O)O(CH 2 ) x —, —(CH 2 ) x —O—(CH 2 ) x —, and —(CH 2 ) x —S—S—(CH 2 ) x —, where x at each occurrence is an integer independently selected from 1 to 20;

R 2 and R 3 are independently selected from the group consisting of hydrogen, C 1 -C 20 alkyl, and C 6 -C 12 aryl;

m is an integer from 1 to 20;

p is an integer from 1 to 20; and

n is an integer from about 10 to about 500.

12. A monomer having the formula:

wherein,

R 1 is selected from the group consisting of hydrogen, fluorine, trifluoromethyl, cyano, C 1 -C 20 alkyl, and C 6 -C 12 aryl,

R 2 , and R 3 are independently selected from hydrogen and C 1 -C 6 alkyl, X is O or NH,

n is an integer from 1 to 20,

m is an integer from 1 to 20, and

p is an integer from 1 to 20.

13. A polymer or copolymer having repeating units, wherein one or more repeating units comprise a zwitterionic phosphatidylserine moiety, wherein the one or more zwitterionic phosphatidylserine polymers have repeating units having the formula:

wherein

* indicates the point of attachment of the repeating unit to other repeating units in the polymer or copolymer, or polymer or copolymer terminal groups;

B is a polymer backbone;

L 2 is a linker group selected from —(CH 2 ) x —, —C(═O)NH(CH 2 ) x —, —C(═O)O(CH 2 ) x —, —C(═O)OC(═O)O(CH 2 ) x —, —(CH 2 ) x —O—(CH 2 ) x —, and —(CH 2 ) x —S—S—(CH 2 ) x —, where x at each occurrence is an integer independently selected from 1 to 20;

R 2 and R 3 are independently selected from the group consisting of hydrogen, C 1 -C 20 alkyl, and C 6 -C 12 aryl;

m is an integer from 1 to 20;

p is an integer from 1 to 20; and

n is an integer from about 10 to about 500.

14. A polymer or copolymer of claim 13 having repeating units having the formula:

wherein

* indicates the point of attachment of the repeating unit to other repeating units in the polymer or copolymer, or the polymer or copolymer terminal groups;

R 1 is selected from the group consisting of hydrogen, fluorine, trifluoromethyl, cyano, C 1 -C 20 alkyl, and C 6 -C 12 aryl;

R 2 and R 3 are independently selected from hydrogen and C 1 -C 6 alkyl;

X is 0 or NH;

n is an integer from 1 to 20;

m is an integer from 1 to 20;

p is an integer from 1 to 20; and

a is an integer from about 10 to about 500.

Assignments (2)
CONFIRMATORY LICENSE Recorded Jun 1, 2023
From: UNIVERSITY OF WASHINGTON
To: NATIONAL SCIENCE FOUNDATION
Reel/Frame 063823/0995 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 9, 2020
From: JIANG, SHAOYI; LI, BOWEN; JAIN, PRIYESH
To: UNIVERSITY OF WASHINGTON
Reel/Frame 054016/0417 →
Continuity (2)
Provisional Application 62647534 · Mar 23, 2018
Related Publication 20210023228A1 · Jan 28, 2021
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