Compound and pharmaceutical composition for preventing or treating obesity or metabolic syndrome comprising thereof
The present invention provides a compound represented by the following Chemical Formula 1 or a pharmaceutically acceptable salt thereof which can be effectively used for preventing or treating obesity or metabolic syndrome, and a pharmaceutical composition comprising the same. in Chemical Formula 1, R 1 and R 2 are the same as defined in the specification.
1. A compound represented by the following Chemical Formula 1 or a pharmaceutically acceptable salt thereof,
in Chemical Formula 1,
R 1 is -L 1 -(phenyl),
R 2 is hydrogen, or -L 2 -(phenyl),
L 1 is C 1-5 alkylene, and
L 2 is C 1-5 alkylene,
with the proviso that not both R 1 and R 2 are benzyl.
2. The compound or a pharmaceutically acceptable salt thereof according to claim 1 , wherein
L 1 is —CH 2 —, —CH 2 CH 2 —, —CH 2 CH 2 CH 2 —, or —CH 2 CH 2 CH 2 CH 2 —.
3. The compound or a pharmaceutically acceptable salt thereof according to claim 1 , wherein
L 2 is —CH 2 —, —CH 2 CH 2 —, —CH 2 CH 2 CH 2 —, or —CH 2 CH 2 CH 2 CH 2 —.
4. The compound or a pharmaceutically acceptable salt thereof according to claim 1 , wherein
R 1 is —CH 2 -(phenyl), and
R 2 is hydrogen, —CH 2 CH 2 -(phenyl), —CH 2 CH 2 CH 2 -(phenyl), or —CH 2 CH 2 CH 2 CH 2 -(phenyl).
5. The compound or a pharmaceutically acceptable salt thereof according to claim 1 , wherein
R 1 and R 2 are equal to each other.
6. The compound or a pharmaceutically acceptable salt thereof according to claim 5 , wherein
R 1 and R 2 are —CH 2 CH 2 -(phenyl), —CH 2 CH 2 CH 2 -(phenyl), or —CH 2 CH 2 CH 2 CH 2 -(phenyl).
7. The compound or a pharmaceutically acceptable salt thereof according to claim 1 , wherein
the compound is any one selected from the group consisting of:
1) 2-(3,4-diphenethoxybenzylamino)ethanol,
2) 2-(3,4-bis(3-phenylpropoxy)benzylamino)ethanol,
3) 2-(3,4-bis(4-phenylbutoxy)benzylamino)ethanol,
4) 2-(benzyloxy)-5-((2-hydroxyethylamino)methyl)phenol,
5) 2-(4-(benzyloxy)-3-phenethoxybenzylamino)ethanol,
6) 2-(4-(benzyloxy)-3-(3-phenylpropoxy)benzylamino)ethanol, and
7) 2-(4-(benzyloxy)-3-(4-phenylbutoxy)benzylamino)ethanol.
8. A method for preventing or treating obesity or metabolic syndrome in a subject in need thereof, comprising administering to the subject the compound or a pharmaceutically acceptable salt thereof according to claim 1 .
9. The method according to claim 8 , wherein the metabolic syndrome is any one selected from the group consisting of myocardial infarction, arteriosclerosis, hyperlipidemia, hypertension, cerebral infarction, cerebral hemorrhage, fatty liver, and type 2 diabetes mellitus.