Dielectric materials
The present disclosure describes methods, devices and systems comprising materials comprising dielectrics. In various aspects, electrodes layered or imbedded with these dielectrics provide enhanced properties for a wide range of applications, such as the enhanced separation of analytes, such as biological molecules or particles (nucleic acids, viruses) with an electrokinetic field.
1. A device for capturing analytes comprising:
a) an electrode configured to generate an electrokinetic field region; and
b) a layer in contact with at least a portion of the electrode, wherein the layer comprises a dielectric material of about 5 angstroms to about 25 angstroms in thickness, wherein the device increases the total yield of analyte capture as compared to a device that lacks a layer or has a layer that is more than 25 angstroms in thickness.
2. The device of claim 1 , wherein the electrokinetic field comprises a dielectrophoretic field, an electrothermal field, an electroosmotic field, or a combination thereof.
3. The device of claim 1 , wherein the dielectric material comprises a metalloid oxide, metalloid nitride, metalloid carbide, metalloid silicide, or combination thereof.
4. The device of claim 3 , wherein the metalloid is selected from the group consisting of boron, silicon, germanium, arsenic, antimony, tellurium, and combinations thereof.
5. The device of claim 1 , wherein the dielectric material further comprises a metal.
6. The device of claim 5 , wherein the metal is selected from the group consisting of platinum, ruthenium, rhodium, iridium, manganese, magnesium, tungsten, zirconium, chromium, gold, iron, aluminum, tantalum, gallium, copper, silver, brass, zinc, tin, nickel, palladium, titanium, cobalt, indium, bismuth, lead, lanthanum, hafnium, yttrium, calcium, strontium, barium, cadmium, mercury, thallium, antimony, germanium, and combinations thereof.
7. The device of claim 1 , wherein the dielectric material comprises an organic or inorganic polymer.
8. The device of claim 1 , wherein the dielectric material comprises a ceramic.
9. The device of claim 1 , wherein the dielectric material has a dielectric constant of about 2 to about 10.
10. The device of claim 1 , wherein the layer comprises a material selected from the group consisting of silicon, silicon oxide, silicon nitride, silicon carbide, titanium oxide, germanium, polytetrafluoroethylene, neoprene, polyvinylidene fluoride, silicon dioxide, titanium dioxide, fluorosilicate glass, polyimide, fluorinated polyimide, methylsilsesquioxane, polyarylene ether, polyethylene, polystyrene, calcium carbonate, and combinations thereof.
11. The device of claim 1 , wherein the electrode comprises a conductive material.
12. The device of claim 11 , wherein the mole ratio of dielectric to conductive material is about 0.01:2 to about 99:1.
13. The device of claim 11 , wherein the mole ratio of dielectric to conductive material is about 0.3:2.
14. The device of claim 11 , wherein the conductive material comprises at least one of the group consisting of platinum, gold, aluminum, tantalum, gallium arsenide, copper, silver, brass, zinc, tin, nickel, silicon, palladium, titanium, graphite, carbon, and combinations thereof.
15. A method for manufacturing the device of claim 1 comprising depositing the layer on the electrode using at least one deposition technique.
16. A method for isolating an analyte in a sample, the method comprising:
(a) applying the sample to a device comprising an electrode configured to generate an electrokinetic field region and a layer in contact with at least a portion of the electrode, wherein the layer comprises a dielectric material of about 5 angstroms to about 25 angstroms in thickness, wherein the device increases the total yield of analyte capture as compared to a device that lacks a layer or has a layer that is more than 25 angstroms in thickness;
(b) producing at least one AC dielectrophoretic and/or AC electrokinetic field region; and
(c) isolating the analyte in the AC dielectrophoretic and/or AC electrokinetic field region.
17. The method of claim 16 , wherein the presence of the layer results in at least a 5 fold increase in analyte capture on the surface when compared to a device without the layer.