HEMP EXTRACT FOR TREATMENT OF PAIN IN ANIMALS
The present disclosure relates to methods of treating pain in veterinary subjects using pharmaceutical compositions and dosage forms comprising hemp extract. In an aspect, provided herein is a pharmaceutical composition comprising hemp extract and a carrier, wherein the hemp extract comprises cannabidiol; and cannabidiolic acid; wherein the ratio of cannabidiol to cannabidiolic acid is about 0.6:1 to about 1:0.6.
1 . A pharmaceutical composition comprising hemp extract and a carrier, wherein the hemp extract comprises:
cannabidiol; and
cannabidiolic acid;
wherein the ratio of cannabidiol to cannabidiolic acid is about 0.6:1 to about 1:0.6.
2 . The pharmaceutical composition of claim 1 , where in hemp extract further comprises:
cannabigerolic acid;
D9-tetrahydrocannabinol; and
cannabichromene.
3 . The pharmaceutical composition of claim 1 , wherein the hemp extract further comprises four or more of the following:
α-pinene;
β-myrcene;
β-pinene;
δ-limonene;
linalool;
β-caryophyllene;
α-humulene;
nerolidol 2;
guaiol;
caryophyllene oxide; and
α-bisabolol.
4 - 17 . (canceled)
18 . The pharmaceutical composition of claim 1 , wherein the composition is formulated in a carrier.
19 . The pharmaceutical composition of claim 18 , wherein the carrier is selected from the group consisting of linseed oil, olive oil, fish oil, salmon oil, coconut oil, catnip oil, sesame oil, and grapeseed oil.
20 . The pharmaceutical composition of claim 19 , wherein the carrier is grapeseed oil.
21 . The pharmaceutical composition of claim 19 , wherein the carrier is catnip oil.
22 - 27 . (canceled)
28 . The pharmaceutical composition of claim 1 , wherein the composition is formulated as a chew for oral administration.
29 - 32 . (canceled)
33 . A pharmaceutical composition comprising hemp extract and a carrier, wherein the hemp extract comprises four or more of:
α-pinene;
β-myrcene;
β-pinene;
δ-limonene;
linalool;
β-caryophyllene;
α-humulene;
nerolidol 2;
guaiol;
caryophyllene oxide; and
α-bisabolol.
34 - 46 . (canceled)
47 . The pharmaceutical composition of claim 33 wherein the pharmaceutical composition is formulated as a chew for oral administration.
48 - 73 . (canceled)
74 . A dosage form comprising the pharmaceutical composition of claim 1 and one or more pharmaceutically acceptable additives, flavoring agents, surfactants, and adjuvants.
75 - 113 . (canceled)
114 . A dosage form comprising:
glucosamine HCl;
chondroitin sulfate (76%) or hyaluronic acid;
brewer's yeast;
arabic gum;
guar gum;
a flavoring agent;
hemp extract;
glycerin;
sunflower lecithin; and
water.
115 - 119 . (canceled)
120 . A dosage form comprising:
hemp extract;
peanut butter;
rice bran;
glucosamine HCl;
sweet potato;
dry molasses;
sorbic acid
brewer's yeast;
sugar;
water;
glycerin;
potato starch;
dehydrated peanut butter;
rice starch; and
guar gum.
121 - 131 . (canceled)
132 . A method for treating or reducing pain in a veterinary subject in need thereof, comprising administering to the subject a therapeutically effective amount of the pharmaceutical composition of claim 1 .
133 - 150 . (canceled)
151 . A method for treating or reducing pain associated with arthritis, post-operative pain, acute pain, dental pain, pain associated with gingivitis, or multi joint pain in a veterinary subject in need thereof, comprising administering to the subject a therapeutically effective amount of hemp extract.
152 - 165 . (canceled)
166 . A method of achieving an area under the curve from 0 time to 24 hours of between 42.4 and 3048 ng hr/ml for cannabidiol in a veterinary subject comprising administering to the subject an effective amount of hemp extract.
167 . (canceled)
168 . The pharmaceutical composition of claim 1 , wherein the hemp extract does not comprise terpenes.
169 . A dosage form comprising the pharmaceutical composition of claim 33 and one or more pharmaceutically acceptable additives, flavoring agents, surfactants, and adjuvants.
170 . A method for treating or reducing pain in a veterinary subject in need thereof, comprising administering to the subject a therapeutically effective amount of the pharmaceutical composition of claim 33 .
171 . A method for treating or reducing pain in a veterinary subject in need thereof, comprising administering to the subject a therapeutically effective amount of the dosage form of claim 74 .
172 . A method for treating or reducing pain in a veterinary subject in need thereof, comprising administering to the subject a therapeutically effective amount of the dosage form of claim 114 .
173 . A method for treating or reducing pain in a veterinary subject in need thereof, comprising administering to the subject a therapeutically effective amount of the dosage form of claim 117 .
174 . A method for treating or reducing pain in a veterinary subject in need thereof, comprising administering to the subject a therapeutically effective amount of the dosage form of claim 120 .