IP Library Granted Patent US 12,544,348
Granted Patent B2
US 12,544,348 · App. 17/046,950 · Granted Feb 10, 2026

Methods for treating APOE4/4-associated disorders

Inventors: Yadong Huang (Daville, CA); Alice Taubes (San Francisco, CA); Phil Nova (San Francisco, CA); Marina Sirota (San Francisco, CA)
Assignees: The J. David Gladstone Institutes; The Regents of the University of California
A61K31/196A61K9/0019A61K9/0053A61K9/7023A61P25/28C12Q1/6883C12Q2600/106C12Q2600/156
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Quick Facts
Patent No.
US 12,544,348
App. No.
17/046,950
Granted
Feb 10, 2026
Kind
B2
Abstract

The present disclosure provides methods of treating Alzheimer's Disease (AD) and rescuing cognitive deficits associated with AD in a subject having an apoE4/4 genotype, by administering a therapeutically effective amount of the loop-diuretic bumetanide to the subject. Also disclosed are kits for performing the method, including one or more doses of a bumetanide formulation; and which may also include instructions for treating a patient having an apoE4/4 genotype by administering bumetanide, and/or instructions and reagents for testing/identifying a subject having an apoE4/4 genotype.

Claims (22)

1 . A method of preventing or treating Alzheimer's Disease (AD) in a subject having an apoE4/4 genotype, the method comprising administering a therapeutically effective amount of bumetanide to the subject.

2 . The method of claim 1 , wherein the administering comprises administering bumetanide to the subject at a dose of 0.05 mg/kg/day or less.

3 . The method of claim 2 , wherein the administering comprises administering bumetanide to the subject at a dose of 0.02 mg/kg/day or less.

4 . The method of claim 1 , wherein the bumetanide is formulated as an oral dosage form comprising a pharmaceutically acceptable carrier, and wherein the oral dosage form is administered orally.

5 . The method of claim 4 , wherein the oral dosage form is administered once daily as a capsule, a tablet, a disintegrating tablet or lozenge, or a sachet.

6 . The method of claim 1 , wherein the bumetanide is administered intravenously or parenterally.

7 . The method of claim 1 , wherein the bumetanide is provided in a transdermal patch.

8 . The method of claim 1 , wherein the subject is a mammal.

9 . The method of claim 8 , wherein the mammal is a human.

10 . A method of preventing or treating Alzheimer's Disease in a subject having an apoE4/4 genotype, the method comprising:

a) identifying a subject as having an apoE4/4 genotype; and

b) administering a therapeutically effective amount of bumetanide to the subject.

11 . The method of claim 10 , wherein the identifying comprises performing a PCR-based DNA analytic method on a biological sample from the subject.

12 . The method of claim 11 , further comprising isolating the biological sample from the subject.

13 . The method of claim 10 , wherein the administering comprises administering bumetanide to the subject as a dose of 0.05 mg/kg/day or less.

14 . The method of claim 13 , wherein the administering comprises administering bumetanide to the subject as a dose of 0.02 mg/kg/day or less.

15 . The method of claim 10 , wherein the bumetanide is formulated as an oral dosage form comprising a pharmaceutically acceptable carrier, and wherein the oral dosage form is administered orally.

16 . The method of claim 15 , wherein the oral dosage form is administered once daily as a capsule, a tablet, a disintegrating tablet or lozenge, or a sachet.

17 . The method of claim 10 , wherein the bumetanide is administered intravenously or parenterally.

18 . The method of claim 10 , wherein the bumetanide is provided in a transdermal patch.

19 . The method of claim 10 , wherein the subject is a mammal.

20 . The method of claim 19 , wherein the mammal is a human.

Assignments (4)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 8, 2026
From: HUANG, YADONG
To: THE J. DAVID GLADSTONE INSTITUTES
Reel/Frame 073406/0485 →
CONFIRMATORY LICENSE Recorded Oct 26, 2023
From: J. DAVID GLADSTONE INSTITUTES
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 065364/0968 →
CORRECTIVE ASSIGNMENT TO CORRECT THE APPLICATION NUMBER 17/406,950 PREVIOUSLY RECORDED AT REEL: 061027 FRAME: 0225. ASSIGNOR(S) HEREBY CONFIRMS THE ASSIGNMENT. Recorded Sep 20, 2022
From: TAUBES, ALICE; NOVA, PHIL; SIROTA, MARINA
To: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Reel/Frame 061594/0957 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 8, 2022
From: TAUBES, ALICE; NOVA, PHIL; SIROTA, MARINA
To: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Reel/Frame 061027/0225 →
Continuity (2)
Provisional Application 62656898 · Apr 12, 2018
Related Publication 20210228519A1 · Jul 29, 2021
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