Granted Patent B2

US 12,559,778 · App. 17/047,683 · Granted Feb 24, 2026

Inventors: Damien Brichant (Sarzeau, FR); Eric Valery (Lyons, FR)

Assignee: NOVASEP PROCESS SOLUTIONS

C12P19/02A23L5/273A23L5/49A23L29/30B01D15/1871B01D15/426C12P19/24C13K11/00A23V2002/00

Abstract

Claims (41)

1 . A method for producing a fructose composition comprising the following successive steps:

provision of an initial composition comprising glucose;

concentration of the initial composition by evaporation of water to obtain a concentrated initial composition;

isomerization of glucose to fructose from the concentrated initial composition, making it possible to obtain an intermediate composition;

purification of the intermediate composition in a multicolumn chromatography system, making it possible to obtain a glucose-rich raffinate and a fructose-rich extract;

concentration of the extract by evaporation of water;

wherein the intermediate composition is not subjected to a concentration step by evaporation of water between the isomerization step and the purification step, and

wherein the purification step includes injection of water as an eluent, the ratio of the mass flow rate of eluent to the mass flow rate of dry matter of the produced fructose composition, being from 0.5 to 1.3, wherein the raffinate is recycled and added to the initial composition prior to the concentration of the initial composition step, wherein a part of the intermediate composition is added to the extract before concentrating it, wherein the volume of intermediate composition subjected to the purification step is from 0.13 to 0.40 BV, and wherein the ratio of the injected volume of eluent to the volume of intermediate composition subjected to the purification step is 0.885 or less.

2 . The method of claim 1 , further comprising a step of removing residual color from the extract prior to the concentration of the extract step.

3 . The method of claim 1 , further comprising a demineralization step between the isomerization step and the purification step.

4 . The method of claim 1 , wherein the purification is carried out at a temperature greater than or equal to 50° C.

5 . The method of claim 1 , wherein the intermediate composition which is subjected to the purification step has a dry matter mass concentration of 45 to 55%.

6 . The method of claim 1 , wherein the dry matter mass concentration of the intermediate composition varies by less than 5%, between the end of the isomerization step and the beginning of the purification step.

7 . The method of claim 1 , wherein the multicolumn chromatography system comprises a plurality of columns and intercolumn fluidic links, and wherein the velocity of the fluids in the intercolumn fluidic links is greater than 0.5 m/s.

8 . The method of claim 1 , wherein the method is devoid of any evaporation step other than that of concentrating the initial composition and that of concentrating the extract.

9 . The method of claim 1 ,

the injected volume of eluent being from 0.12 to 0.24 BV.

10 . A method for producing a fructose composition comprising the following successive steps:

provision of an initial composition comprising glucose;

concentration of the initial composition by evaporation of water to obtain a concentrated initial composition;

isomerization of glucose to fructose from the concentrated initial composition, making it possible to obtain an intermediate composition;

purification of the intermediate composition in a multicolumn chromatography system, making it possible to obtain a glucose-rich raffinate and a fructose-rich extract;

concentration of the extract by evaporation of water;

the mass concentration of dry matter of the intermediate composition at the end of the isomerization step being equal to the mass concentration of dry matter of the intermediate composition subjected to the purification step within 5%, and

the purification includes injection of water as an eluent, the ratio of the mass flow rate of eluent to the mass flow rate of dry matter of the produced fructose composition, being from 0.5 to 1.3, wherein the raffinate is recycled and added to the initial composition prior to the concentration of the initial composition step, wherein a part of the intermediate composition is added to the extract before concentrating it, wherein the volume of intermediate composition subjected to the purification step is from 0.13 to 0.40 BV, and wherein the ratio of the injected volume of eluent to the volume of intermediate composition subjected to the purification step is 0.885 or less.

11 . A method for producing a fructose composition comprising the following successive steps:

provision of an initial composition comprising glucose;

concentration of the initial composition by evaporation of water to obtain a concentrated initial composition;

isomerization of glucose to fructose from the concentrated initial composition, making it possible to obtain an intermediate composition;

purification of the intermediate composition in a multicolumn chromatography system, making it possible to obtain a glucose-rich raffinate and a fructose-rich extract;

concentration of the extract by evaporation of water;

wherein the intermediate composition is not subjected to a concentration step by evaporation of water between the isomerization step and the purification step, and

wherein the purification step includes injection of water as an eluent, the ratio of the mass flow rate of eluent to the mass flow rate of dry matter of the produced fructose composition, being from 0.5 to 1.3, and the method further comprises a step of removing residual color from the extract prior to the concentration of the extract step, wherein a part of the intermediate composition is added to the extract before concentrating it, wherein the volume of intermediate composition subjected to the purification step is from 0.13 to 0.40 BV, and wherein the ratio of the injected volume of eluent to the volume of intermediate composition subjected to the purification step is 0.885 or less.

12 . A method for producing a fructose composition comprising the following successive steps:

provision of an initial composition comprising glucose;

concentration of the initial composition by evaporation of water to obtain a concentrated initial composition;

isomerization of glucose to fructose from the concentrated initial composition, making it possible to obtain an intermediate composition;

purification of the intermediate composition in a multicolumn chromatography system, making it possible to obtain a glucose-rich raffinate and a fructose-rich extract;

concentration of the extract by evaporation of water;

wherein the intermediate composition is not subjected to a concentration step by evaporation of water between the isomerization step and the purification step, and

wherein the purification step includes injection of water as an eluent, the ratio of the mass flow rate of eluent to the mass flow rate of dry matter of the produced fructose composition, being from 0.5 to 1.3, and wherein the multicolumn chromatography system comprises a plurality of columns and intercolumn fluidic links, wherein the velocity of the fluids in the intercolumn fluidic links is greater than 0.5 m/s, wherein a part of the intermediate composition is added to the extract before concentrating it, wherein the volume of intermediate composition subjected to the purification step is from 0.13 to 0.40 BV, and wherein the ratio of the volume of intermediate composition subjected to the purification step to the injected volume of eluent is 0.885 or less.

Assignments (3)

Priority Claims (1)

Continuity (1)

References Cited (41)