Compositions and uses thereof
The present invention relates to a composition comprising Lactobacillus rhamnosus GG (LGG) (ATCC 53103) and/or a bioactive extract of LGG to increase the expression of filaggrin or profilaggrin, for use in treating skin or mucosa barrier dysfunctions or defects. The present invention also comprises the use of a composition comprising Lactobacillus rhamnosus GG (LGG) (ATCC 53103) and/or a bioactive extract of LGG to increase the expression of filaggrin or profilaggrin, for use in the manufacture of a medicament for use in treating skin barrier dysfunctions. Also disclosed is a use of a composition comprising Lactobacillus rhamnosus GG (LGG) (ATCC 53103) and/or a bioactive extract of LGG to increase the expression of filaggrin or profilaggrin, for use in the manufacture of a cosmetic composition for use in improving the appearance and/or texture of the skin. The present invention also comprises a method of treating skin barrier dysfunctions comprising administering a composition comprising Lactobacillus rhamnosus GG (LGG) and/or a bioactive extract of LGG to increase the expression of filaggrin or profilaggrin.
1. A method of treating a skin or mucosa barrier dysfunction or defect associated with lowered and/or disrupted filaggrin or profilaggrin expression comprising topically administering a composition comprising a bioactive extract of Lactobacillus rhamnosus GG (LGG) (ATCC 53103), wherein from 8.8 μg/cm 2 to 26.5 μg/cm 2 of the bioactive extract of Lactobacillus rhamnosus GG (LGG) (ATCC 53103) is administered or applied to, or on, the skin or mucosa barrier surface.
2. The method according to claim 1 , wherein the LGG and/or a bioactive extract of LGG is in lysate form.
3. The method according to claim 1 , wherein the method increases and/or repairs skin barrier function.
4. The method according to claim 1 , wherein the skin barrier dysfunction comprises atopic dermatitis.
5. The method according to claim 1 , wherein the composition further comprises one or more pharmaceutically acceptable ingredients or excipients.
6. The method according to claim 1 , which is formulated in the form of a cream, gel, ointment or oil.