Tricyclic heterocycle compounds useful as HIV integrase inhibitors
The present invention relates to Tricyclic Heterocycle Compounds of Formula (I): (I) and pharmaceutically acceptable salts or prodrug thereof, wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 and n are as defined herein. The present invention also relates to compositions comprising at least one Tricyclic Heterocycle Compound, and methods of using the Tricyclic Heterocycle Compounds for treating or preventing HIV infection in a subject.
1. A compound of the formula:
or a pharmaceutically acceptable salt thereof,
wherein:
each occurrence of R 1 is independently halo or C 1-3 alkyl, wherein said alkyl groups are optionally substituted with one to three halo;
R 2 is hydrogen, methyl or ethyl;
R 3 is hydrogen, methyl or ethyl;
R 4 is hydrogen, methyl or ethyl;
R 5 is hydrogen, C 1-3 alkyl, (C 1-3 alkyl)OR 7 or phenyl;
or R 4 and R 5 can be taken together with the carbon atom to which they are attached to form a 5- or 6-membered heterocyclyl group;
R 6 is hydrogen, C 1-6 alkyl or (C 1-6 alkyl)OR 7 ;
or R 5 and R 6 can be taken together with the atoms between them to form a 6-membered heterocyclyl group;
R 7 is hydrogen or C 1-3 alkyl, which is optionally substituted with one to three halo;
n is an integer between one and three.
2. The compound of claim 1 wherein each R 1 is halo, or a pharmaceutically acceptable salt thereof.
3. The compound of claim 1 wherein R 2 is hydrogen, or a pharmaceutically acceptable salt thereof.
4. The compound of claim 1 wherein R 3 is hydrogen, or a pharmaceutically acceptable salt thereof.
5. The compound of claim 1 wherein R 4 is hydrogen or methyl, or a pharmaceutically acceptable salt thereof.
6. The compound of claim 1 wherein R 4 is hydrogen, or a pharmaceutically acceptable salt thereof.
7. The compound of claim 1 wherein R 5 is hydrogen, methyl, ethyl, CH 2 OCH 3 or phenyl, or a pharmaceutically acceptable salt thereof.
8. The compound of claim 1 wherein R 6 is methyl, ethyl or CH 2 CH 2 OCH 3 , or a pharmaceutically acceptable salt thereof.
9. The compound of claim 1 wherein R 4 and R 5 can be taken together with the carbon atom to which they are attached to form a 5-membered heterocyclyl group, or a pharmaceutically acceptable salt thereof.
10. The compound of claim 1 wherein R 4 and R 5 can be taken together with the carbon atom to which they are attached to form a tetrahydrofuranyl group, or a pharmaceutically acceptable salt thereof.
11. The compound of claim 1 wherein R 5 and R 6 can be taken together with the atoms between them to form a morpholinyl group, or a pharmaceutically acceptable salt thereof.
12. The compound of claim 1 selected from:
or a pharmaceutically acceptable salt thereof.
13. A pharmaceutical composition comprising an effective amount of a compound according to claim 1 , or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.
14. A method for the inhibition of HIV integrase in a subject in need thereof which comprises administering to the subject an effective amount of the compound according to claim 1 , or a pharmaceutically acceptable salt thereof.
15. A method for the treatment of infection by HIV or for the treatment of AIDS in a subject in need thereof, which comprises administering to the subject an effective amount of the compound according to claim 1 , or a pharmaceutically acceptable salt thereof.
16. The pharmaceutical composition of claim 13 , further comprising one or more additional therapeutic agents selected from, raltegravir, lamivudine, abacavir, ritonavir, dolutegravir, arunavir, atazanavir, emtricitabine, tenofovir, elvitegravir, rilpivirine, EFdA, doravirine and lopinavir.
17. A method for the treatment of infection by HIV or for the treatment of AIDS in a subject in need thereof, which comprises administering to the subject an effective amount of the compound according to claim 1 , or a pharmaceutically acceptable salt thereof, further comprising administering to the subject one or more additional therapeutic agents selected from raltegravir, lamivudine, abacavir, ritonavir, dolutegravir, arunavir, atazanavir, emtricitabine, tenofovir, elvitegravir, rilpivirin, EFdA, doravirine and lopinavir, wherein the amounts administered of the compound of claim 1 and the one or more additional therapeutic agents, are together effective to treat infection by HIV or to treat, prevent or delay the onset or progression of AIDS.