Granted Patent
B2
US 11,369,624 · App. 17/068,902 · Granted Jun 28, 2022
Salts of prodrugs of piperazine and substituted piperidine antiviral agents
Inventors:
Yasutsugu Ueda (Wallingford, CT); Timothy P. Connolly (Wallingford, CT); John F. Kadow (Branford, CT); Nicholas A. Meanwell (Wallingford, CT); Tao Wang (Wallingford, CT); Chung-Pin H. Chen (Wallingford, CT); Kap-Sun Yeung (Wallingford, CT); Zhongxing Zhang (Wallingford, CT); David Kenneth Leahy (Somerset, NJ); Shawn K. Pack (Plainsboro, NJ); Nachimuthu Soundararajan (Kendall Park, NJ); Pierre Sirard (St. Jean sur Richelieu, CA); Kathia Levesque (Ste-Catherine, CA); Dominique Thoraval (Candiac, CA)
A61K31/675A61K31/497A61K31/519A61K45/06C07C215/10C07D471/04C07F9/062C07F9/5728C07F9/6561C07F9/65515C07F9/65586
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Abstract
This invention provides for prodrug Compounds I, pharmaceutical compositions thereof, and their use in treating HIV infection. wherein: X is C or N with the proviso that when X is N, R 1 does not exist; W is C or N with the proviso that when W is N, R 2 does not exist; V is C; E is hydrogen or a pharmaceutically acceptable salt thereof; and Y is selected from the group consisting of Also, this invention provides for intermediate Compounds II useful in making prodrug Compounds I. wherein: L and M are independently selected from the group consisting of C 1 -C 6 alkyl, phenyl, benzyl, trialkylsilyl, -2,2,2-trichloroethoxy and 2-trimethylsilylethoxy.
Claims (1)
1. The compound
Continuity (13)
Provisional Application
60635231
· Dec 10, 2004
Provisional Application
60553320
· Mar 15, 2004