Granted Patent
B2
US 12,122,829 · App. 17/076,359 · Granted Oct 22, 2024
Human alpha-folate receptor chimeric antigen receptor
Inventors:
Daniel J. Powell, Jr. (Bala Cynwyd, PA); Mariangela Figini (Milan, IT); Silvana Canevari (Milan, IT)
Assignees:
The Trustees of the University of Pennsylvania; Fondazione IRCCS Istituto Nazionale Dei Tumori
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Abstract
The invention provides compositions and methods for treating ovarian cancer. Specifically, the invention relates to administering a genetically modified T cell having α-folate receptor (FRα) binding domain and CD27 costimulatory domain to treat ovarian cancer. In an embodiment, the FRα binding domain is fully human, thereby preventing a host immune response.
Claims (3)
1. A chimeric antigen receptor (CAR), wherein the CAR comprises the amino acid sequence of SEQ ID NO: 2.
2. The CAR of claim 1 , further comprising a ligand that specifically binds with CD83.
3. A chimeric antigen receptor (CAR) encoded by the nucleic acid sequence of SEQ ID NO: 13.
Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Aug 31, 2023
From: FIGINI, MARIANGELA; CANEVARI, SILVANA
To: FONDAZIONE IRCCS ISTITUTO NAZIONALE DEI TUMORI
Reel/Frame 064764/0516 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Aug 31, 2023
From: POWELL, DANIEL J., JR.
To: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
Reel/Frame 064764/0653 →
Continuity (4)
Division
14432664
Provisional Application
61710493
· Oct 5, 2012