IP Library › Granted Patent US 11,925,679
Granted Patent B2
US 11,925,679 · App. 17/077,806 · Granted Mar 12, 2024

H3.3 CTL peptides and uses thereof

Inventors: Hideho Okada (Mill Valley, CA); Yafei Hou (Palo Alto, CA)
Assignee: The Regents of the University of California
A61K39/0011A61K38/03A61K38/17A61K38/19C07K14/47C07K14/4748G01N33/5014G01N33/505A61K2039/5158A61K2039/80
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Quick Facts
Patent No.
US 11,925,679
App. No.
17/077,806
Granted
Mar 12, 2024
Kind
B2
Abstract

Peptides that generate an immune response to glioma-related H3.3 proteins and methods of their use are provided.

Claims (4)

1. A polypeptide sequence comprising a T-cell receptor (TCR) or a fragment thereof, wherein the TCR or the fragment thereof binds to a peptide/major histocompatibility complex (WIC) complex, and wherein the peptide in the peptide/WIC complex consists of 10 to 12 amino acids and comprises (R/A)MSAP(S/A)TGGV (SEQ ID NO:1).

2. The polypeptide sequence according to claim 1 , wherein the peptide consists of RMSAPSTGGV (SEQ ID NO: 2).

3. The polypeptide sequence according to claim 1 , wherein the arginine (R) in SEQ ID NO:1 is citrullinated.

4. The polypeptide sequence according to claim 1 , wherein the TCR or the fragment thereof comprises one or more heterologous sequences.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 13, 2023
From: OKADA, HIDEHO; HOU, YAFEI
To: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Reel/Frame 065537/0870 →
CONFIRMATORY LICENSE Recorded Nov 13, 2023
From: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 065549/0209 →
Continuity (6)
Division 16569615 · Sep 12, 2019
Continuation 15613837 · Jun 5, 2017
Continuation In Part PCTUS2016030849 · May 4, 2016
Provisional Application 62212508 · Aug 31, 2015
Provisional Application 62157362 · May 5, 2015
Related Publication 20210038704A1 · Feb 11, 2021