MODIFIED RELEASE PREPARATIONS CONTAINING OXCARBAZEPINE AND DERIVATIVES THEREOF
Controlled-release preparations of oxcarbazepine and derivatives thereof for once-a-day administration are disclosed. The inventive compositions comprise solubility- and/or release enhancing agents to provide tailored drug release profiles, preferably sigmoidal release profiles. Methods of treatment comprising the inventive compositions are also disclosed.
1 . A method of treating seizures, comprising administering to a subject in need thereof a controlled-release formulation comprising oxcarbazepine, wherein the amount of oxcarbazepine is effective to produce a steady state blood level of monohydroxy derivative of oxcarbazepine in the range of about 2 μg/ml to about 10 μg/ml, and wherein the treatment exhibits reduced side-effects.
2 . The method of claim 1 , wherein the formulation is effective in minimizing fluctuations between C min and C max of monohydroxy derivative of oxcarbazepine.
3 . The method of claim 2 , wherein C max levels of monohydroxy derivative of oxcarbazepine are in the range of about 6 μg/ml to about 10 μg/ml and C min levels of monohydroxy derivative of oxcarbazepine are in the range of about 2 μg/ml to about 5 μg/ml.
4 . The method of claim 1 , wherein the controlled-release formulation is administered to the subject once-a-day.
5 . The method of claim 1 , wherein the amount of oxcarbazepine is 600 mg.
6 . The method of claim 1 , wherein the seizure is an epileptic seizure.
7 . The method of claim 6 , wherein the epileptic seizure is a partial seizure or a generalized tonic-clonic seizure.
8 . The method of claim 6 , wherein the epileptic seizure is a generalized tonic-clonic seizure.
9 . The method of claim 1 , wherein the subject is an adult or child.