WATER SOLUBLE CANNABINOID POWDERS
Materials and methods for making a water-soluble cannabinoid powder are provided. For example, the present disclosure provides a method for making a water-soluble cannabinoid powder by mixing a cannabinoid with a molten composition of a water soluble carrier, a hydrocolloid, and a surfactant, cooling the mixture, and grinding the cooled mixture. Formulations containing the water soluble powder to deliver an effective amount of the one or more cannabinoids to a subject in need thereof are also provided.
1 . A method for making a water-soluble cannabinoid powder comprising:
mixing a cannabinoid-containing composition and a molten composition comprising a water-soluble carrier, a hydrocolloid, and a surfactant to provide a molten mixture, wherein the water-soluble carrier comprises a sugar, a sugar alcohol, or a combination thereof;
cooling the molten mixture to provide a cooled solid; and
comminuting the cooled solid to provide a water-soluble cannabinoid-containing powder.
2 . The method of claim 1 , further comprising making the cannabinoid-containing composition by mixing a cannabinoid-containing oil and a solvent, optionally ethanol.
3 . The method of claim 2 , wherein mixing includes ultrasonic homogenization.
4 . The method of claim 2 , wherein the cannabinoid containing oil is heated to about 50-60° C. before being mixed with the solvent.
5 . The method of claim 2 , wherein the cannabinoid-containing oil comprises a whole plant cannabis extract, distillate, individual isolated cannabinoids, and combinations thereof.
6 . The method of claim 2 , wherein the cannabinoid-containing oil and solvent are mixed at a weight ratio within a range of about 1-5:5-1 cannabinoid-containing oil: solvent.
7 . The method of claim 2 , further comprising removing the solvent from the molten mixture.
8 . The method of claim 1 , wherein the molten composition includes about 50-90 wt % water-soluble carrier and about 1-30 wt % hydrocolloid.
9 . The method of claim 1 , wherein the water-soluble carrier is selected from the group consisting of sucrose, glucose, sorbitol, xylitol, maltitol, mannitol, isomalt, erythritol and combinations thereof.
10 . The method of claim 1 , wherein the hydrocolloid is selected from the group consisting of gum acacia, carob gum, carrageenan, ghatti gum, guar gum, karaya gum, pectin, tragacanth gum, locust bean gum, xanthan gum and combinations thereof.
11 . The method of claim 1 , wherein the surfactant is a natural emulsifier, optionally quillaja extract.
12 . The method of claim 1 , wherein the water-soluble carrier is selected from the group consisting of sucrose, glucose, sorbitol, xylitol, maltitol, mannitol, isomalt, erythritol and combinations thereof, the hydrocolloid is selected from the group consisting of gum acacia, carob gum, carrageenan, ghatti gum, guar gum, karaya gum, pectin, tragacanth gum, locust bean gum, xanthan gum and combinations thereof, and the surfactant is quillaja extract.
13 . The method of claim 1 , further comprising preparing the molten composition by heating the water-soluble carrier to obtain a molten liquid and adding the hydrocolloid and the surfactant.
14 . The method of claim 10 , wherein heating includes subjecting the water-soluble carrier to a temperature of at least 90° C., optionally about 110-120° C.
15 . The method of claim 1 , wherein the molten composition further comprises one or more ingredients selected from the group consisting of colorants, flavorants, taste modifiers, buffering agents, pH adjusting agents, stabilizers, and sweeteners.
16 . The method of claim 15 , wherein the molten composition includes a buffering agent or a pH adjusting agent in an amount sufficient to adjust or maintain an alkaline pH, optionally a pH within a range of about 7.5-9.0.
17 . The method of claim 1 , wherein comminuting the cooled mixture comprises manually breaking the cooled solid into coarse fragments, mixing the coarse fragments with at least one hydrocolloid, and grinding the mixture of the coarse fragments and hydrocolloid into a powder.
18 . A water-soluble cannabinoid powder made by a process comprising:
mixing a cannabinoid-containing composition and a molten composition comprising a water-soluble carrier, a hydrocolloid, and a surfactant to provide a molten mixture, wherein the water-soluble carrier comprises a sugar, a sugar alcohol, or a combination thereof;
cooling the molten mixture to provide a cooled solid; and
comminuting the cooled solid to provide a water-soluble cannabinoid powder.
19 . A method of treating a subject in need of a biological effect of a cannabinoid comprising:
administering to the subject, an effective amount of a water-soluble cannabinoid powder, made by a process comprising:
mixing a cannabinoid-containing composition and a molten composition comprising a water-soluble carrier, a hydrocolloid, and a surfactant to provide a molten mixture, wherein the water-soluble carrier comprises a sugar, a sugar alcohol, or a combination thereof;
cooling the molten mixture to provide a cooled solid; and
comminuting the cooled solid to provide a water-soluble cannabinoid powder.
20 . The method of claim 19 , wherein the water-soluble cannabinoid powder is administered to the subject in a tablet, a liquid solution, or personal care composition.