Granted Patent B2

US 12,419,997 · App. 17/083,863 · Granted Sep 23, 2025

Inventors: Tak-Sing Wong (University Park, PA); Jing Wang (University Park, PA); Birgitt Boschitsch (University Park, PA)

Assignee: The Penn State Research Foundation

A61L31/14A61F5/445A61L31/10C08G77/24A61L2400/10A61L2420/02A61L2420/08

Abstract

Claims (25)

1. A substrate having a surface, the surface being an untreated surface, the substrate comprising:

a layer of polyphenol formed on the surface;

a silanization layer formed directly on the polyphenol layer, the silanization layer comprising an array of straight-chain polysiloxanes having ends anchored to the polyphenol layer and opposite ends extending away from the polyphenol layer; and

a lubricant disposed over the silanization layer.

2. The substrate of claim 1 , wherein the surface of the substrate before forming the layer of polyphenol and layer of salinization has an average roughness of less than 1 μm.

3. The substrate of claim 1 , wherein the silanization layer has a thickness of from about 2 nm to about 20 nm.

4. The substrate of claim 1 , wherein the lubricant comprises one or more of an omniphobic lubricant, a hydrophobic lubricant and/or a hydrophilic lubricant.

5. The substrate of claim 1 , wherein the lubricant comprises one or more of silicone oils or mineral oils.

6. The substrate of claim 1 , wherein the surface comprises a polystyrene, polyvinyl chloride, polyethylene, polypropylene, polycarbonate, silicone, rubber, ethylene vinyl acetate, poly(vinylidene chloride) or combinations thereof.

7. The substrate of claim 1 , wherein the silanization layer comprises an array of linear polysiloxanes polymerized from a di-alkoxy silane in a solution which is applied to the polyphenol layer.

8. The substrate of claim 1 , wherein the polyphenol layer comprises a catechol amine.

9. The substrate of claim 1 , wherein the polyphenol comprises a tannic acid, epigallocatechin gallate, epicatechin gallate, epigallocatechin, raspberry ellagitannin, theaflavin-3-gallate, tellimagrandin II, or combinations thereof.

10. The substrate of claim 1 , wherein the polyphenol layer has a thickness of less than about 100 nm.

11. The substrate of claim 1 , wherein the surface comprises a polymer.

12. The substrate of claim 1 , wherein the surface comprises a metal, ceramic, glass or a combination thereof.

13. The substrate of claim 1 , wherein the substrate comprises a medical device having a polymeric surface.

14. The substrate of claim 1 , wherein the substrate comprises an ostomy bag having a polymeric surface.

15. The substrate of claim 1 , wherein the substrate comprises a catheter.

16. The substrate of claim 1 , wherein the substrate comprises a medical device.

17. The substrate of claim 16 , wherein the silanization layer comprises an array of linear polysiloxanes polymerized from a di-alkoxy silane in the solution and wherein the lubricant comprises one or more of silicone oils, mineral oils, plant oils, and perfluorinated oils.

18. A substrate having a surface, comprising:

a layer of polyphenol formed on the surface;

a silanization layer formed directly on the polyphenol layer, the silanization layer comprising an array of straight-chain polysiloxanes having ends anchored to the polyphenol layer and opposite ends extending away from the polyphenol layer, the silanization layer polymerized from a solution including: (i) a polymerizable silane selected from the group consisting of dimethyldimethoxysilane, dimethoxy-methyl (3,3,3-trifluoropropyl)silane, dimethoxy(methyl)octylsilane, diethoxydimethylsilane, (ii) a solvent and (iii) an acid catalyst; and

a lubricant disposed over the silanization layer.

19. The substrate according to claim 18 , wherein the surface is untreated before the layer of polyphenol is formed on the surface.

Assignments (2)

Continuity (3)

References Cited (14)