Method of treating disorders associated with chronic inflammation
In one aspect, a method of treating a disorder associated with chronic inflammation includes administering to an individual in need thereof a therapeutically effective amount of isomyosmine or a pharmaceutically acceptable salt thereof. In some aspects, the disorder is a cancer, an autoimmune disorder, hypertension, or autism. In other aspects, isomyosmine is administered to treat viral infections or disorders associated with elevated levels of hydrogen peroxide and/or other Reactive Oxygen Species (ROS).
1. A method of treating a disorder associated with chronic inflammation comprising administering to an individual in need thereof a pharmaceutical composition containing a therapeutically effective amount of isomyosmine or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable vehicle therefor.
2. The method of claim 1 , wherein the therapeutically effective amount is from about 0.01 to about 50 mg/kg/day.
3. The method of claim 1 , wherein the therapeutically effective amount is from about 0.1 to about 25 mg/kg/day.
4. The method of claim 1 , wherein the pharmaceutically acceptable salt is isomyosmine hydrochloride.
5. The method of claim 1 , wherein the disorder is a cancer.
6. The method of claim 5 , wherein the cancer is a human cervical cancer.
7. The method of claim 5 wherein the therapeutically effective amount of isomyosmine or pharmaceutically acceptable salt thereof modifies a tumor microenvironment by reducing the concentration of reactive oxygen species.
8. The method of claim 7 wherein the therapeutically effective amount of isomyosmine or pharmaceutically acceptable salt thereof modifies a tumor microenvironment by reducing the concentration of hydrogen peroxide.
9. The method of claim 1 wherein the method further comprises treating the individual with chemotherapy.
10. The method of claim 1 , wherein the disorder is fibrosis.
11. The method of claim 1 , wherein the disorder is asthma.