IP Library Granted Patent US 11,535,632
Granted Patent B2
US 11,535,632 · App. 17/084,713 · Granted Dec 27, 2022

Solid forms of an S1P-receptor modulator

Inventors: Stéphane De Lombaert (Brisbane, CA); Ana Rosario Mool Sarno (San Mateo, CA); Michael A. Christie (Phoenixville, PA); Edward L. Ciolkowski (Webster, NY); Susana del Rio Gancedo (Cambridge, GB); Joseph Stephen Harris (Cambridge, GB); Lucy Kristina Mapp (Cambridge, GB); Mateusz Bogumil Pitak (Cambridge, GB); Scott L. Childs (Atlanta, GA)
Assignee: ESCAPE Bio, Inc.
C07D498/04C07B2200/13
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Quick Facts
Patent No.
US 11,535,632
App. No.
17/084,713
Granted
Dec 27, 2022
Kind
B2
Abstract

This application relates to solid forms of an S1P-receptor modulator, which are useful in the treatment of diseases or disorders associated with activity of S1P, including CNS disorders.

Claims (4)

1. A solid form of Compound 1 having the formula:

wherein the solid form is crystalline, and has characteristic XRPD peaks at about 13.9, about 19.0, and about 21.5 degrees 2-theta.

2. The solid form of claim 1 , wherein the solid form has further characteristic XRPD peaks at about 4.7, about 9.3, about 15.8, about 18.6, and about 27.4 degrees 2-theta.

3. The solid form of claim 1 , wherein the solid form has further characteristic XRPD peaks at about 4.7, about 9.3, about 12.4, about 13.1, about 14.8, about 15.8, about 16.3, about 18.1, about 18.6, about 19.5, about 21.8, about 22.1, about 22.4, about 23.0, about 23.3, about 23.5, about 23.8, about 24.6, about 25.5, about 26.4, about 27.0, about 27.4, about 27.5, about 28.1, about 29.4, about 29.8, about 29.9, about 31.4, about 32.7, about 34.4, about 35.9, about 36.4, about 37.7, and about 39.6 degrees 2-theta.

Assignments (8)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 23, 2023
From: RENOVO RESEARCH, LLC
To: ESCAPE BIO, INC.
Reel/Frame 064687/0742 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 17, 2022
From: DE LOMBAERT, STÉPHANE; MOLLO SARNO, ANA ROSARIO
To: E-SCAPE BIO, INC.
Reel/Frame 061438/0839 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 17, 2022
From: CHRISTIE, MICHAEL A.; CIOLKOWSKI, EDWARD L.
To: SYNER-G PHARMA CONSULTING, LLC
Reel/Frame 061438/0856 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 17, 2022
From: SYNER-G PHARMA CONSULTING, LLC
To: E-SCAPE BIO, INC.
Reel/Frame 061438/0865 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 17, 2022
From: DEL RIO GANCEDO, SUSANA; HARRIS, JOSEPH STEPHEN; MAPP, LUCY KRISTINA; PITAK, MATEUSZ BOGUMIL
To: JOHNSON MATTHEY PLC
Reel/Frame 061438/0873 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 17, 2022
From: JOHNSON MATTHEY PLC
To: E-SCAPE BIO, INC.
Reel/Frame 061438/0880 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 17, 2022
From: CHILDS, SCOTT L.
To: RENOVO RESEARCH, LLC
Reel/Frame 061438/0888 →
CHANGE OF NAME Recorded Oct 17, 2022
From: E-SCAPE BIO, INC.
To: ESCAPE BIO, INC.
Reel/Frame 061686/0192 →
Continuity (2)
Provisional Application 62928412 · Oct 31, 2019
Related Publication 20210139502A1 · May 13, 2021