Implantable drug delivery port
A drug delivery port including a port housing having an inner sidewall defining a fill port cavity and a fill port washer in direct contact with a perimeter edge of the inner sidewall of the port housing such that an intersection between the washer and the perimeter edge define a plurality of filter channels having a cross-sectional flow area of about 0.001 mm 2 to about 0.5 mm 2 that lie within the fluid pathway of the delivery port. The delivery port also includes a port cover coupled and a pierceable septum compressed between the fill port washer and the port cover configured to allow a needle to pierce through the septum to deliver an injectable fluid to the fill port cavity.
1 . A method of forming an implantable drug delivery port comprising a port housing, a fill port washer, a pierceable septum, and a port cover, the method comprising:
machining the port housing to include an inner sidewall and needle stop defining a fill port cavity for receiving an injectable fluid, wherein the inner sidewall comprises a perimeter edge;
machining at least one of the perimeter edge of the inner sidewall or a first side of the port washer to form a plurality of filter channels, wherein each filter channel defines a cross-sectional flow area when the first side of the port washer is seated in direct contact with the perimeter edge of the inner sidewall; and
coupling the port cover to the port housing so that the pierceable septum is compressed between at least a second side of the fill port washer and the port cover, wherein the port cover defines an aperture positioned over the pierceable septum and is configured so that a needle can pierce through the septum to deliver the injectable fluid to the fill port cavity.
2 . The method of claim 1 , further comprising:
machining the port housing to include an integrated catheter fitting; and
machining the port housing to form a fluid pathway that connects the plurality of filter channels to the catheter fitting.
3 . The method of claim 2 , wherein machining the port housing to form a fluid pathway comprises:
forming a collecting channel coaxially aligned with the fill port cavity and fluidically connected to each of the plurality of filter channels;
machining a first lumen along a central axis of the catheter fitting; and
electrical discharge machining a second lumen to fluidically connect the collecting channel to the first lumen.
4 . The method of claim 1 , wherein coupling the port cover to the port housing comprises:
press fitting the port cover to the port housing, wherein at least one of the port cover or the port housing comprises at least one friction-fit retainer that temporarily secures the port housing to the port cover; and
welding the port housing to the port cover.