ESTER NITRATES DERIVATIVES OF AROMATIC ALDEHYDES WITH MULTIPLE PHARMALOGIC PROPERTIES TO TREAT SICKLE CELL DISEASE
The invention provides new aromatic aldehyde compounds that have greater potency in increasing the affinity of Hb for oxygen, greater potency for preventing sickling, and additional pharmacologic properties that ameliorate other symptoms of SCD. The invention further provides methods for treating SCD by providing a subject having SCD with a compound according to the invention.
1 - 57 . (canceled)
58 . A method for treating a subject having sickle cell disease (SCD), comprising administering to the subject a therapeutically effective amount of a compound of the formula:
wherein R 1 is H, OH, alkyl, alkoxy, halogen, aryl, or O-aryl;
wherein R 2 is H or NO 2 ;
wherein X, Y, and Z are the same or different and are C or N; and
wherein n is 1-5, and
pharmaceutically acceptable salts thereof.
59 . A method of claim 58 wherein the compound has the general formula
wherein R 1 is H, OH, alkyl, alkoxy, halogen, aryl, or O-aryl; and X, Y, and Z are the same or different and are C or N; and pharmaceutically acceptable salts thereof.
60 . The method of claim 59 wherein the compound as the formula
and pharmaceutically acceptable salts thereof.
61 . The method of claim 59 wherein the compound has the formula
and pharmaceutically acceptable salts thereof.
62 . The method of claim 58 wherein the compound has the general formula
wherein R 1 is H, OH, alkyl, alkoxy, halogen, aryl, or O-aryl; and X, Y, and Z are the same or different and are C or N; and pharmaceutically acceptable salts thereof.