IP Library › Granted Patent US 11,566,007
Granted Patent B2
US 11,566,007 · App. 17/089,035 · Granted Jan 31, 2023

Ras inhibitors

Inventors: Elena S. Koltun (Foster City, CA); James Cregg (Belmont, CA); Adrian L. Gill (Menlo Park, CA); Andreas Buckl (San Francisco, CA); Yang Liu (Foster City, CA)
Assignee: Revolution Medicines, Inc.
C07D245/04A61P35/00
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Quick Facts
Patent No.
US 11,566,007
App. No.
17/089,035
Granted
Jan 31, 2023
Kind
B2
Abstract

The disclosure features macrocyclic compounds, and pharmaceutical compositions and protein complexes thereof, capable of inhibiting Ras proteins, and their uses in the treatment of cancers.

Claims (26)

1. A compound, or a pharmaceutically acceptable salt thereof, selected from the following compounds:

Ex #

Structure

A202

A248

A276

A277

A278

A279

A286

A287

A288

A314

A330

A331

A340

A347

A447

A468

A506

A520

A521

A694

A728

.

2. A pharmaceutical composition comprising a compound, or a pharmaceutically acceptable salt thereof, of claim 1 , and a pharmaceutically acceptable excipient.

Assignments (2)
SECURITY INTEREST Recorded Jun 25, 2025
From: REVOLUTION MEDICINES, INC.
To: WILMINGTON TRUST, NATIONAL ASSOCIATION, AS AGENT
Reel/Frame 071721/0025 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 14, 2021
From: KOLTUN, ELENA S.; CREGG, JAMES; GILL, ADRIAN L.; AGGEN, JAMES; BURNETT, G. LESLIE; PITZEN, JENNIFER; BUCKL, ANDREAS; KNOX, JOHN E.; LIU, YANG
To: REVOLUTION MEDICINES, INC.
Reel/Frame 054926/0085 →
Cited By (1)
US 12,624,053